Argyrophil organizer region proteins (AgNORs) in adenohypophysial cells and adenomas of the human pituitary.
Argyrophil organizer region proteins (AgNORs) in adenohypophysial cells and adenomas of the human pituitary.
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人类垂体腺垂体细胞和腺瘤中的嗜银组织者区域蛋白 (AgNOR)。
DOI：
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发表时间：
1989
期刊：
影响因子：
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通讯作者：
K. Kovacs
中科院分区：
文献类型：
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作者：
L. Ştefăneanu;É. Horváth;K. Kovacs
核仁组成区（NORs），声称代表有价值的肿瘤增殖的标志物，可视化石蜡切片上的嗜银方法，并在18个非肿瘤性腺垂体和132垂体肿瘤计数。AgNOR计数与非肿瘤细胞和腺瘤细胞的激素活性无相关性。在垂体腺瘤中，平均AgNOR值高于相应的非肿瘤细胞类型。然而，一些腺瘤，尤其是生长激素（GH）和催乳素（PRL）细胞腺瘤，AgNOR读数在非肿瘤细胞范围内。长效生长抑素类似物和溴隐亭治疗降低了GR和PRL产生肿瘤的AgNOR计数。大多数，但不是所有的侵袭性和/或复发性腺瘤有高AgNOR计数。在促肾上腺皮质激素细胞癌中，AgNORs并不高于腺瘤。目前，这些不一致的结果限制了AgNORs作为垂体瘤细胞增殖的可靠标志物的应用。进一步的研究可能有助于建立这种有前途的方法在垂体病理学的价值。
Nucleolar organizer regions (NORs), claimed to represent valuable markers of tumor proliferation, were visualized on paraffin sections by an argyrophil method and counted in 18 nontumorous adenohypophyses and 132 pituitary tumors. The AgNOR counts could not be correlated with the hormonal activity of nontumorous and adenoma cells. In pituitary adenomas, the mean AgNOR values were higher than in their corresponding nontumorous cell types. Some adenomas, especially growth hormone (GH), and prolactin (PRL) cell adenomas, however, had AgNOR readings in the range of nontumorous cells. Long-acting somatostatin analog and bromocriptine treatment decreased AgNOR counts in GR- and PRL-producing tumors. Most, but not all invasive and/or recurrent adenomas had high AgNOR counts. In a corticotroph carcinoma, AgNORs were not higher than in the adenomas. These inconsistent results limit, at the present time, the use of AgNORs as reliable markers of cell proliferation in pituitary tumors. Further studies may help to establish the value of this promising method in pituitary pathology.