SOCIAL REARING EFFECTS ON HPA AXIS ACTIVITY OVER EARLY DEVELOPMENT AND IN RESPONSE TO STRESS IN RHESUS-MONKEYS
SOCIAL REARING EFFECTS ON HPA AXIS ACTIVITY OVER EARLY DEVELOPMENT AND IN RESPONSE TO STRESS IN RHESUS-MONKEYS
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DOI：
10.1002/dev.420260802
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发表时间：
1993-12-01
影响因子：
2.2
通讯作者：
CLARKE, AS
中科院分区：
文献类型：
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作者：
CLARKE, AS
以前的研究已经发现了在不同社会环境中饲养的非人灵长类动物之间行为和心理生理差异的证据，然而，很少有人对动物的早期发育进行纵向研究。在这项研究中，HPA轴的活动进行了评估，通过测量促肾上腺皮质激素和皮质醇值在生命的前6个月，并在两个压力的住房过渡48个婴儿恒河猴，无论是母亲或同伴饲养。ACTH和皮质醇值下降，在头6个月在两个饲养组。同龄人饲养的猴子在出生后的前6个月表现出较低的ACTH水平，但在此期间，饲养组的基础皮质醇值没有差异。母亲饲养的动物表现出更大的ACTH反应被转移到一个新的笼子的温和的压力，和雄性猴子表现出更高的值比女性。母亲饲养的动物在笼子过渡期间表现出最大的皮质醇增加。两组都表现出ACTH和皮质醇的增加，以应对与抚养他们的伴侣分离和与不熟悉的同龄人一起居住的更严重的压力。母亲饲养的动物再次表现出最大的增长，促肾上腺皮质激素在这些事件的反应，但皮质醇的增加是相似的性别和饲养组。这些结果表明，在应对压力事件的性别和养育历史的相互作用。(C)John Wiley & Sons，Inc.
Previous studies have found evidence of behavioral and psychophysiological differences between nonhuman primates reared in different social environments, however, few of these have employed longitudinal study of the animals over early development. In this study, HPA axis activity was assessed via measurement of ACTH and cortisol values over the first 6 months of life and in response to two stressful housing transitions in 48 infant rhesus monkeys that were either mother- or peer-reared. ACTH and cortisol values declined over the first 6 months in both rearing groups. Peer-reared monkeys showed lower levels of ACTH over the Brst 6 months of life than mother-reared, but the rearing groups did not differ in basal cortisol values over this period. Mother-reared animals showed a greater ACTH response to the mild stress of being moved to a new cage, and male monkeys showed higher values than females. Mother-reared animals showed the largest cortisol increase in response to the caging transition. Both groups showed increases in ACTH and cortisol in response to the more severe stress of separation from their rearing partners and housing with unfamiliar agemates. Mother-reared animals again showed the largest increase in ACTH in response to these events, but increases in cortisol were similar among both sexes and rearing groups. These results suggest an interaction of sex and rearing history in response to stressful events. (C) 1993 John Wiley & Sons, Inc.