Angiotensin-converting enzyme activity in tissues of the rainbow trout.
Angiotensin-converting enzyme activity in tissues of the rainbow trout.
复制标题
虹鳟鱼组织中血管紧张素转换酶的活性。
DOI：
10.1002/jez.1402300122
复制
发表时间：
1984
期刊：
影响因子：
--
通讯作者：
Olson,KR
中科院分区：
文献类型：
--
作者：
Galardy,R;Podhasky,P;Olson,KR
在虹鳟鱼匀浆组织和血浆中测定血管紧张素转换酶活性（ACE）。血管紧张素转换酶（ACE）的生理作用进行了检查注射血管紧张素转换酶抑制剂卡托普利（SQ 14，225）到背主动脉的慢性插管鳟鱼。鳃和斯坦尼斯小体显示出最大的ACE活性，并且在每湿重基础上含有比血浆多30倍的酶。在骨骼肌、肝脏和肾脏组织中几乎检测不到ACE。注射后1 min内，Captopril降低背主动脉压（DAP）。在接下来的30分钟内，压力下降到低于对照5-7 mm Hg，并在该水平下再保持1小时。因为鳃接收全部的心输出量，所以它们就像哺乳动物的肺一样，处于调节血浆激素水平的理想位置。血管紧张素II（AII）的激活似乎只是鳃代谢能力的一个例子。
Angiotensin‐converting enzyme activity (ACE) was assayed in homogenized rainbow trout tissues and plasma. The physiological role of ACE was examined by injection of the ACE inhibitor captopril (SQ 14,225) into the dorsal aorta of chronically cannulated trout. Gills and corpuscles of Stannius exhibited greatest ACE activity and contained over 30 times more enzyme than plasma on a per‐wet‐weight basis. ACE was barely detectable in skeletal muscle, liver, and kidney tissues. Captopril lowered dorsal aortic pressure (DAP) within 1 min after injection. Pressure fell 5–7 mm Hg below control over the next 30 min and remained at this level for an additional hour. Because the gills receive the entire cardiac output they are, like the mammalian lungs, ideally situated to regulate plasma hormone levels. Activation of angiotensin II (AII) appears to be only one example of branchial metabolic capability.