The Role of Reactive Oxygen Species in the Pathogenesis of Alzheimer's Disease, Parkinson's Disease, and Huntington's Disease: A Mini Review.
The Role of Reactive Oxygen Species in the Pathogenesis of Alzheimer's Disease, Parkinson's Disease, and Huntington's Disease: A Mini Review.
复制标题
活性氧在阿尔茨海默氏病，帕金森氏病和亨廷顿氏病的发病机理中的作用：迷你综述。
DOI：
10.1155/2016/8590578
复制
发表时间：
2016
影响因子：
--
通讯作者：
Akbar MD
中科院分区：
文献类型：
--
作者：
Manoharan S;Guillemin GJ;Abiramasundari RS;Essa MM;Akbar M;Akbar MD
神经退行性疾病不仅影响老年人的生活质量，而且影响他们的寿命。所有形式的神经退行性疾病对老年人都有巨大的影响。这些脑疾病的主要威胁包括记忆的进行性丧失、阿尔茨海默病（AD）、运动障碍、帕金森病（PD）和不能行走、说话和思考的亨廷顿病（HD）。氧化应激和线粒体功能障碍被强调为脑退行性疾病的中心特征。氧化应激是一种由于氧化剂和抗氧化剂状态失衡而发生的病症，已知其在神经退行性疾病（包括AD、PD和HD）的病理生理学中起重要作用。大量的研究已经利用氧化应激生物标志物来调查这些神经退行性疾病的严重程度，并且药物是可用的，但这些药物仅治疗症状。在传统医学中，大量药用植物已被用于治疗这些神经退行性疾病的症状。广泛的研究使用合适的动物模型科学地验证了天然产品对神经退行性疾病的有益作用。这篇简短的综述集中在氧化应激在AD、PD和HD发病机制中的作用，以及天然产物对这些疾病的保护作用。
Neurodegenerative diseases affect not only the life quality of aging populations, but also their life spans. All forms of neurodegenerative diseases have a massive impact on the elderly. The major threat of these brain diseases includes progressive loss of memory, Alzheimer's disease (AD), impairments in the movement, Parkinson's disease (PD), and the inability to walk, talk, and think, Huntington's disease (HD). Oxidative stress and mitochondrial dysfunction are highlighted as a central feature of brain degenerative diseases. Oxidative stress, a condition that occurs due to imbalance in oxidant and antioxidant status, has been known to play a vital role in the pathophysiology of neurodegenerative diseases including AD, PD, and HD. A large number of studies have utilized oxidative stress biomarkers to investigate the severity of these neurodegenerative diseases and medications are available, but these only treat the symptoms. In traditional medicine, a large number of medicinal plants have been used to treat the symptoms of these neurodegenerative diseases. Extensive studies scientifically validated the beneficial effect of natural products against neurodegenerative diseases using suitable animal models. This short review focuses the role of oxidative stress in the pathogenesis of AD, PD, and HD and the protective efficacy of natural products against these diseases.