Psychoses precipitated by psychotomimetic drugs. A follow-up study.
Psychoses precipitated by psychotomimetic drugs. A follow-up study.
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拟精神病药物引发的精神病。
DOI：
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发表时间：
1977
影响因子：
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通讯作者：
M. Bowers
中科院分区：
文献类型：
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作者：
M. Bowers
15 名在使用拟精神病药物（可能主要是 LSD）后出现长期精神病反应的患者在 1.9 至 5.8 年后进行了随访。两名患者自杀。大约一半患者的结果相对较好，一半患者的结果较差。讨论了与结果测量相关的初始临床情况的各个方面。人们认为，使用拟精神病药物后易出现长期精神病反应的可能性可能与易患躁狂抑郁/精神分裂情感谱系疾病的遗传易感性有关。在某些情况下，这种脆弱性可能涉及中枢血清素神经元系统。
Fifteen patients who developed prolonged psychotic reactions following psychotomimetic drug use (probably primarily LSD) were followed up 1.9 to 5.8 years later. Two patients had committed suicide. Approximately half of the patients had a relatively good outcome and half did poorly. Aspects of the initial clinical picture that correlated with outcome measures are discussed. The possibility is considered that vulnerability to a prolonged psychotic reaction following psychotomimetic drug use may be related to a genetic vulnerability to illnesses in the manic-depressive/schizo-affective spectrum. In some instances this vulnerability may implicate central serotonergic neuronal systems.