Acute Monitoring of Genitourinary Function Using Intrafascicular Electrodes: Selective Pudendal Nerve Activity Corresponding to Bladder Filling, Bladder Fullness, and Genital Stimulation
Acute Monitoring of Genitourinary Function Using Intrafascicular Electrodes: Selective Pudendal Nerve Activity Corresponding to Bladder Filling, Bladder Fullness, and Genital Stimulation
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DOI：
10.1016/j.urology.2014.05.021
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发表时间：
2014-09-01
期刊：
影响因子：
2.1
通讯作者：
Normann, Richard A.
中科院分区：
文献类型：
--
作者：
Mathews, Kiran S.;Wark, Heather A. C.;Normann, Richard A.
目的探讨使用高空间密度的穿透神经束内电极的微电极阵列，用于选择性记录阴部神经活动引起的各种生殖泌尿stimulation.MATERIALS和METHODS猫麻醉与α-氯醛糖和高密度犹他州倾斜电极阵列（48微电极; 200 μ m的间距）植入阴部神经急性experimentals.Materials和方法。神经活动记录在膀胱充盈，自发反射性扩张引起的膀胱收缩，和触觉体感stimulation.Results的神经束内植入阴部神经电极能够选择性地记录神经活动，对应于各种泌尿生殖系统的刺激。在所有7只实验动物中，共有10个微电极记录了由膀胱充盈或扩张诱发的膀胱收缩选择性驱动的神经单元。结论微电极阵列植入阴部神经束内可用于选择性记录反映膀胱状态和泌尿生殖道触觉刺激的神经反应。这项工作为开发未来用于恢复膀胱功能的植入式闭环神经假体装置奠定了基础。(C)2014爱思唯尔公司
OBJECTIVE To investigate the use of a microelectrode array with a high spatial density of penetrating intrafascicular electrodes for selective recording of pudendal nerve activity evoked by a variety of genitourinary stimuli.MATERIALS AND METHODS Felines were anesthetized with alpha-chloralose and high-density Utah slanted electrode arrays (48 microelectrodes; 200-mu m spacing) were implanted into the pudendal nerve for acute experimentation. Neural activity was recorded during bladder filling, spontaneous reflexive distention-evoked bladder contractions, and tactile somatosensory stimulation.RESULTS The intrafascicularly implanted pudendal nerve electrodes were able to selectively record neural activity that corresponded to various genitourinary stimuli. Across all seven experimental animals, a total of 10 microelectrodes recorded neural units that were selectively driven by bladder filling or distention-evoked bladder contractions. Twenty-two electrodes were selectively driven by tactile stimulation.CONCLUSION Microelectrode arrays implanted intrafascicularly into the pudendal nerve can be used to selectively record the neural responses that reflect bladder status and urogenital tactile stimulation. This work sets the stage for developing future implantable closed-loop neuro-prosthetic devices for restoration of bladder function. (C) 2014 Elsevier Inc.