Palladium-catalyzed annulation of arynes by 2-halobenzaldehydes: synthesis of fluoren-9-ones.
Palladium-catalyzed annulation of arynes by 2-halobenzaldehydes: synthesis of fluoren-9-ones.
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DOI：
10.1021/ol0514597
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发表时间：
2005-08
期刊：
影响因子：
5.2
通讯作者：
Xiaoxiang Zhang;R. Larock
中科院分区：
文献类型：
--
作者：
Xiaoxiang Zhang;R. Larock
由2-(三甲基硅基)芳基三氟酸酯和CSF原位生成的芳烃在钯催化剂存在下被邻位卤代芳烃甲醛环化，为高产率合成氟-9-酮提供了一种有用的新方法。[反应：见正文]
Arynes, generated in situ from 2-(trimethylsilyl)aryl triflates and CsF, undergo annulation by o-haloarenecarboxaldehydes in the presence of a Pd catalyst, providing a useful new method for the synthesis of fluoren-9-ones in good yields. [reaction: see text]