Gender difference as a prognostic factor in patients undergoing resection of non-small cell lung cancer
Gender difference as a prognostic factor in patients undergoing resection of non-small cell lung cancer
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DOI：
10.1007/s00595-006-3453-9
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发表时间：
2007-07-01
期刊：
影响因子：
2.5
通讯作者：
Yasumoto, Kosei
中科院分区：
文献类型：
--
作者：
Hanagiri, Takeshi;Sugio, Kenji;Yasumoto, Kosei
目的。我们研究了性别差异对肺癌发病率和死亡率的影响，这是一个备受讨论的话题。方法。我们检查了 1994 年至 2004 年间接受原发性非小细胞肺癌 (NSCLC) 切除术的 491 名男性和 222 名女性临床特征的性别差异。结果。癌症的组织学类型为腺癌（249 例（51%）男性和 182 例（82%）女性），鳞状细胞癌（182 例（37%）男性和 27 例（12%）女性）。女性腺癌的发病率明显更高。女性 IA 期疾病的比例显着高于男性（分别为 45% 和 29%）。男性的 5 年总体生存率为 50%，女性为 63%。在多变量分析中，性别差异是一个独立的预后因素；然而，当排除无关疾病导致的死亡时，预后没有显着差异。结论。尽管腺癌和IA期癌症的较高发病率促成了女性手术的良好效果，但肺癌以外疾病导致的死亡发生率较低是其预后较好的主要原因。
Purpose. We studied the effects of gender difference on the incidence of lung cancer and its mortality rate, which is a subject of much discussion.Methods. We examined gender difference in the clinical features of 491 men and 222 women who underwent resection of primary non-small cell lung cancer (NSCLC) between 1994 and 2004.Results. The histological types of cancer were adenocarcinoma in 249 (51%) of the men and 182 (82%) of the women, and squamous cell carcinoma in 182 (37%) of the men and 27 (12%) of the women. The incidence of adenocarcinoma was significantly higher in the women. The proportion of stage IA disease was significantly higher in the women than in the men (45% vs 29%, respectively). The 5-year overall survival rates were 50% in the men and 63% in the women. In a multivariate analysis, gender difference was an independent prognostic factor; however, when death as a result of unrelated disease was excluded, there was no significant difference in prognosis.Conclusion. Although the higher incidences of adenocarcinoma and stage IA cancer contributed to the good results of surgery in women, the low incidence of death attributed to diseases other than lung cancer was a major reason for their better prognosis.