Effect of undecylenic acid as a topical microbicide against genital herpes infection in mice and guinea pigs
Effect of undecylenic acid as a topical microbicide against genital herpes infection in mice and guinea pigs
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DOI：
10.1016/s0166-3542(98)00055-2
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发表时间：
1999-01-01
影响因子：
7.6
通讯作者：
Bernstein, DI
中科院分区：
文献类型：
--
作者：
Bourne, N;Ireland, J;Bernstein, DI
人们越来越关注使用局部杀微生物剂来帮助预防性传播疾病（STD）的传播。十一烯酸（UA）是一种单饱和脂肪酸，是许多非处方（OTC）抗真菌喷雾粉末中的活性成分，也具有体外抗菌和抗病毒活性，包括单纯疱疹病毒（HSV）活性。因此，我们在小鼠和豚鼠生殖器疱疹模型中评估了UA作为局部抗生殖器HSV感染的杀微生物剂。小鼠在阴道感染HSV-2之前立即阴道内注射20%的聚乙二醇（PEG）载体、单独载体或磷酸盐缓冲盐水（PBS）。用UA预处理可减少感染小鼠的数量(P
There is increasing interest in the use of topical microbicides to help prevent the spread of sexually transmitted diseases (STD). Undecylenic acid (UA), a monosaturated fatty acid, is the active ingredient in a number of over-the-counter (OTC) antifungal spray powders, that also exhibits in vitro antibacterial and antiviral activity, including herpes simplex virus (HSV) activity. We, therefore, evaluated UA as a topical microbicide against genital HSV infection using the murine and guinea pig models of genital herpes. Mice were administered a 20% solution of UA in polyethylene glycol (PEG) vehicle, vehicle alone or phosphate buffered saline (PBS) intravaginally immediately prior to vaginal challenge with HSV-2. Pre-treatment with UA decreased the number of mice that became infected (P