Asymmetric cyclization-carbonylation of cyclic-2-methyl-2-propargyl-1,3-diols
Asymmetric cyclization-carbonylation of cyclic-2-methyl-2-propargyl-1,3-diols
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DOI：
10.1016/s0040-4039(02)00049-7
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发表时间：
2002-02-18
影响因子：
1.8
通讯作者：
Akita, H
中科院分区：
文献类型：
--
作者：
Kato, K;Tanaka, M;Akita, H
The first example of asymmetric cyclization-carbonylation of cyclic-2-methyl-2-propargyl-1,3-diols 1 catalyzed by palladium(II) with chiral bisoxazolines was investigated. The reaction of 1 in the presence of palladium(II)-chiral ligands/p-benzoquinone in methanol at 0 to -45degreesC under carbon monoxide atmosphere (balloon) afforded (E)-bicyclic-beta-alkoxyacrylates 2 in excellent yields with moderate enantioselectivities. (C) 2002 Elsevier Science Ltd. All rights reserved.
