RCAI-39, 41, 53, 100, 127 and 128, the analogues of KRN7000, activate mouse natural killer T cells to produce Th2-biased cytokines by their administration as liposomal particles
RCAI-39, 41, 53, 100, 127 and 128, the analogues of KRN7000, activate mouse natural killer T cells to produce Th2-biased cytokines by their administration as liposomal particles
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DOI：
10.1039/c1md00067e
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发表时间：
2011-07
期刊：
影响因子：
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通讯作者：
T. Tashiro;Y. Ishii;T. Shigeura;R. Nakagawa;H. Watarai;M. Taniguchi;K. Mori
中科院分区：
文献类型：
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作者：
T. Tashiro;Y. Ishii;T. Shigeura;R. Nakagawa;H. Watarai;M. Taniguchi;K. Mori
用磺胺(RCaI-39)、氨基甲酸酯(RCaI-41)、α-二氟甲酰胺(RCaI-100)或N-甲基甲酰胺键(RCaI-127)取代KRN7000的羧胺键，合成了KRN7000的α，α-半乳糖磷脂类似物。测定了它们对小鼠自然杀伤T细胞的生物活性。还考察了截短类似物Och、Rca1-53和β-半乳糖磷脂(Rca1 2 8)的生物活性。所有这些鞘糖脂都通过作为脂质体给药来诱导Th2偏向的细胞因子的产生。其中，含有RCA1-127的脂质体诱导的Th2偏向反应最强。
α-Galactosphingolipid analogues of KRN7000 with a sulfonamide (RCAI-39), a carbamate (RCAI-41), an α,α-difluorocarboxamide (RCAI-100) or an N-methylcarboxamide linkage (RCAI-127) instead of a carboxamide bond of KRN7000 were synthesized. Their bioactivities for mouse natural killer T cells were examined. Bioactivities of truncated analogues, OCH and RCAI-53, and β-galactosphingolipid (RCAI-128) were also examined. All of these glycosphingolipids induced Th2-biased cytokine production by their administration as liposomal particles. Among them, liposomes containing RCAI-127 induced the most potent Th2-biased response.