Parental history of atopic disease and concentration of cord blood IgE
Parental history of atopic disease and concentration of cord blood IgE
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DOI：
10.1046/j.1365-2222.1996.1024365.x
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发表时间：
1996-06-01
影响因子：
6.1
通讯作者：
Peterson, EL
中科院分区：
文献类型：
--
作者：
Johnson, CC;Ownby, DR;Peterson, EL
背景：特应性家族史和脐带血免疫球蛋白E浓度是儿童特应性疾病的预测因子。一些研究表明，父母特应性可能与新生儿免疫球蛋白E有关。目的探讨父母过敏性疾病史是否与脐带血免疫球蛋白E浓度有关。方法研究对象为1987年至1989年间出生的777名新生儿。这些孩子的母亲在怀孕期间完成了一份关于她们自己和孩子父亲的调查问卷，包括父母过敏疾病（过敏、花粉热和哮喘）的医生诊断史。用酶联免疫分析法定量测定脐带血样品中的总免疫球蛋白E水平。结果母亲有特应性疾病史的婴儿脐带血中位免疫球蛋白E浓度较高，特别是有哮喘史的婴儿(P
Background A family history of atopy, and cord blood immunoglobulin E concentration, have been shown to be predictors of atopic disease in children. Several studies have suggested that parental atopy may be related to newborn immunoglobulin E.Objective The purpose of our analysis was to evaluate whether parental history of allergic disease was associated with cord blood immunoglobulin E concentration.Methods The study subjects were from a defined population of 777 newborns delivered between 1987 and 1989. The mothers of these children completed a questionnaire during pregnancy concerning themselves and the child's father, including parental history of physician diagnosis of allergic diseases (allergies, hay fever and asthma). Total immunoglobulin E levels were quantitated in cord blood samples with an enzyme-linked immunoassay.Results Median cord blood immunoglobulin E concentration was higher among infants whose mothers had a history of atopic disease, particularly for those with a history of asthma (P