Molecular Mechanisms of Fat Preference and Overeating
Molecular Mechanisms of Fat Preference and Overeating
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DOI：
10.1196/annals.1441.028
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发表时间：
2008-01-01
期刊：
影响因子：
--
通讯作者：
Besnard, Philippe
中科院分区：
文献类型：
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作者：
Gaillard, Dany;Passilly-Degrace, Patricia;Besnard, Philippe
Obesity is recognized as a worldwide health problem. Overconsumption of fatty foods contributes significantly to this phenomenon. Rodents, like humans, display preferences for lipid-rich foods. Rodents thus provide useful models to explore the mechanisms responsible for this complex feeding behavior resulting from the integration of multiple oral and postoral signals. Over the last decades, the lipid-mediated regulation of food intake has received considerable attention. By contrast, orosensory lipid perception was long thought to involve only textural and olfactory cues. Recent findings have challenged this limited viewpoint. These recent data strongly suggest that the sense of taste also plays significant roles in the spontaneous preference for fatty foods. This paper provides a brief overview of postoral regulation of food intake by lipids and then highlights recent data suggesting the existence of a "fatty taste" which might contribute to lipid overeating and hence to the risk of obesity.
