Peroxiredoxin 5 (PRX5) is correlated inversely to systemic markers of inflammation in acute stroke.
Peroxiredoxin 5 (PRX5) is correlated inversely to systemic markers of inflammation in acute stroke.
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DOI：
10.1161/strokeaha.113.003813
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发表时间：
2014-02
期刊：
影响因子：
8.3
通讯作者：
Becker K
中科院分区：
文献类型：
--
作者：
Kunze A;Zierath D;Tanzi P;Cain K;Becker K
过氧化物还原酶（PRXs）是内源性抗氧化剂，其作为过氧化物和过氧亚硝酸盐清除剂起作用。然而，细胞外PRX显示通过激活Toll样受体在缺血脑内引发炎症。基于这一观察，我们假设缺血性卒中患者血浆PRX浓度与炎症生物标志物相关，并预测不良结局。在一项缺血性卒中患者的前瞻性研究中，将卒中发作后第3天的血浆PRX5浓度和炎症生物标志物相关联，并评估第3天PRX5与3个月结局之间的关联。PRX5浓度可用于98例患者，并且在更严重的卒中患者中较低（P=0.001）。PRX 5与中风后第3天的炎症生物标志物呈负相关，并且不能预测3个月的结果。血浆PRX 5在重度斯托克中降低，并且与全身性炎症的生物标志物负相关。这些数据表明PRX5不是急性卒中中的促炎介质。此外，PRX5和中风严重程度之间的反比关系表明，PRX5在严重中风中被消耗或其产生受损。需要进一步的研究来确定PRX5在中风中的潜在作用。
Peroxiredoxins (PRXs) are endogenous antioxidants that function as peroxide and peroxynitrite scavengers. Extracellular PRXs, however, are shown to initiate inflammation within the ischemic brain through activation of Toll-like receptors. Based on this observation, we hypothesized that plasma PRX concentrations in ischemic stroke would correlate biomarkers of inflammation and predict poor outcome. In a prospective study of patients with ischemic stroke, plasma PRX5 concentrations and inflammatory biomarkers at day 3 after stroke onset were correlated and the association between PRX5 at day 3 and outcome at 3 months assessed. PRX5 concentrations were available for 98 patients and were lower in those with more severe strokes (P=0.001). PRX5 was inversely correlated to biomarkers of inflammation at day 3 after stroke and did not predict 3 month outcome. Plasma PRX5 is decreased in severe stoke and inversely correlated to biomarkers of systemic inflammation. These data suggest that PRX5 is not a pro-inflammatory mediator in acute stroke. Moreover, the inverse relationship between PRX5 and stroke severity suggests that PRX5 is either consumed or its production is impaired in severe stroke. Further study is needed to define the potential role of PRX5 in stroke.