Membrane trafficking in the yeast Saccharomyces cerevisiae model.
Membrane trafficking in the yeast Saccharomyces cerevisiae model.
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DOI：
10.3390/ijms16011509
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发表时间：
2015-01-09
影响因子：
5.6
通讯作者：
Friant S
中科院分区：
文献类型：
--
作者：
Feyder S;De Craene JO;Bär S;Bertazzi DL;Friant S
酿酒酵母（Saccharomycescerevisiae）是最具代表性的真核生物模型之一。分泌途径是第一个被清楚理解的运输途径，这主要归功于20世纪80年代Randy Schekman实验室的工作。他们已经分离出不能分泌胞外酶的酵母sec突变体，并且这些SEC基因被鉴定为编码分泌机制的关键效应子。2013年诺贝尔生理学和医学奖授予了兰迪·谢克曼，詹姆斯·罗斯曼和托马斯·苏德霍夫分享了该奖项。在这里，我们提出了不同的运输途径的酵母S。啤酒。在高尔基体，新合成的蛋白质在通过胞吐或分泌途径（SEC）转运到质膜（PM）或外部介质的蛋白质与通过内体（液泡蛋白分选或VPS途径）或直接（碱性磷酸酶或ALP途径）靶向液泡的蛋白质之间进行分选。质膜蛋白可以通过内吞作用（END）内化并转运至内体，在那里它们在靶向液泡降解的那些和重定向至高尔基体的那些（再循环或RCY途径）之间进行分选。酵母S.酿酒酵母允许鉴定真核细胞中大多数已知的效应物、蛋白复合物和运输途径，并且它们中的大多数在真核生物中是保守的。
The yeast Saccharomyces cerevisiae is one of the best characterized eukaryotic models. The secretory pathway was the first trafficking pathway clearly understood mainly thanks to the work done in the laboratory of Randy Schekman in the 1980s. They have isolated yeast sec mutants unable to secrete an extracellular enzyme and these SEC genes were identified as encoding key effectors of the secretory machinery. For this work, the 2013 Nobel Prize in Physiology and Medicine has been awarded to Randy Schekman; the prize is shared with James Rothman and Thomas Südhof. Here, we present the different trafficking pathways of yeast S. cerevisiae. At the Golgi apparatus newly synthesized proteins are sorted between those transported to the plasma membrane (PM), or the external medium, via the exocytosis or secretory pathway (SEC), and those targeted to the vacuole either through endosomes (vacuolar protein sorting or VPS pathway) or directly (alkaline phosphatase or ALP pathway). Plasma membrane proteins can be internalized by endocytosis (END) and transported to endosomes where they are sorted between those targeted for vacuolar degradation and those redirected to the Golgi (recycling or RCY pathway). Studies in yeast S. cerevisiae allowed the identification of most of the known effectors, protein complexes, and trafficking pathways in eukaryotic cells, and most of them are conserved among eukaryotes.
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影响因子：
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通讯作者：
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