Intercellular transfer mediated by tunneling nanotubes
Intercellular transfer mediated by tunneling nanotubes
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DOI：
10.1016/j.ceb.2008.03.005
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发表时间：
2008-08-01
影响因子：
7.5
通讯作者：
Carvalho, Raquel Negrao
中科院分区：
文献类型：
--
作者：
Gerdes, Hans-Hermann;Carvalho, Raquel Negrao
动物细胞进化出了不同的相互交流机制。2004年，人们报道了一种利用隧道纳米管(TNT)实现细胞间通讯的新途径。这些膜细胞桥在细胞之间形成新生，并介导细胞器、质膜成分和细胞质分子的细胞间转移。对几种细胞类型的TNT样桥的表征表明，细胞骨架组成以及它们连接细胞的方式存在差异，这表明可能存在不同的亚类。此外，越来越多的细胞类型被检测到TNT样结构，支持这样的观点，即它们代表了细胞之间功能连接的一般机制，这在生理条件下可能具有重要意义。
Animal cells have evolved different mechanisms to communicate with one another. In 2004, a new route of cell-to-cell communication mediated by tunneling nanotubes (TNT) was reported. These membranous cell bridges form de novo between cells and mediate the intercellular transfer of organelles, plasma membrane components and cytoplasmic molecules. The characterization of TNT-like bridges from several cell types revealed variations in the cytoskeletal composition as well as in the modality by which they interconnect cells, suggesting that different subclasses may exist. Furthermore, the growing number of cell types for which TNT-like structures were detected, supports the view that they represent a general mechanism for functional connectivity between cells, which could have important implications under physiological conditions.