Training-induced, pressure-lowering effect in SHR - Wide effects on circulatory profile of exercised and nonexercised muscles
Training-induced, pressure-lowering effect in SHR - Wide effects on circulatory profile of exercised and nonexercised muscles
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DOI：
10.1161/01.hyp.0000086201.27420.33
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发表时间：
2003-10-01
期刊：
影响因子：
8.3
通讯作者：
Michelini, LC
中科院分区：
文献类型：
--
作者：
Melo, RM;Martinho, E;Michelini, LC
我们发现，训练诱导的降压作用与股薄肌小动脉壁/管腔比和小静脉生长的降低有关。为了研究这些有益的变化是组织特异性的还是发生在其他肌肉和组织中，我们分析了高血压和训练对运动/非运动肌肉和其他非肌肉组织的微循环特征的影响。自发性高血压大鼠（SHR）和Wistar-Kyoto大鼠进行低强度训练（50% ~ 60%最大运动能力，13周）；同龄的对照大鼠保持久坐不动。训练后和久坐不动的大鼠在休息时用仪器测量血压和心率。对所有组织进行形态学分析（小动脉、毛细血管、小静脉）。训练只在SHR中降低压力和心率。小动脉(内径
We showed that the training-induced, pressure-lowering effect correlates with decreased arteriole wall/lumen ratio and venule growth in the gracilis muscle. To investigate whether these beneficial changes are tissue-specific or occur in other muscles and tissues, we analyzed the effects of hypertension and training on microcirculatory profile of locomotor/nonlocomotor muscles and another nonmuscular tissue. Spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats were submitted to low-intensity training (50% to 60% maximal exercise capacity, 13 weeks); age-matched control rats were kept sedentary. Trained and sedentary rats were instrumented for pressure and heart rate measurements at rest. Morphometric analyses (arterioles, capillaries, venules) were performed in all tissues. Training attenuated pressure and heart rate only in SHR. Arterioles (inner diameter