Strategies to increase cardioprotection through cardioprotective chemokines in chemotherapy-induced cardiotoxicity
Strategies to increase cardioprotection through cardioprotective chemokines in chemotherapy-induced cardiotoxicity
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DOI：
10.1016/j.ijcard.2018.07.087
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发表时间：
2018-10-15
影响因子：
3.5
通讯作者：
Pezeshki, SeyedmohammadSadegh
中科院分区：
文献类型：
--
作者：
Haybar, Habib;Shahrabi, Saeid;Pezeshki, SeyedmohammadSadegh
背景资料：化疗毒副作用是化疗的重要副作用之一，其治疗可使心肌免受损伤及其后果的影响。目的：探讨心肌保护趋化因子及其对心肌的保护机制和途径。方法：检索Google scholar和PubMed中1990 - 2018年的英文文献，检索词“化疗保护“;化疗期间的常规心脏保护策略如血管紧张素转换酶抑制剂和β-受体阻滞剂具有心脏保护作用。心脏保护机制和策略可以为肿瘤学家提供几种通过使用有效的心脏保护剂来保护心脏系统的方法。趋化因子如SDF-1 α、IL-6、IL-8、IL-12和G-CSF是心脏保护性趋化因子。结论：除了β受体阻滞剂和ACE抑制剂外，通过诱导产生心肌保护趋化因子的途径来刺激心肌保护趋化因子的产生也具有较强的保护作用。心肌保护途径的一个不明确之处是JAK 2/STAT 3途径与IL-6产生途径相联系，在心肌缺血区域诱导细胞内粘附分子-1，这一过程对心肌保护没有益处，而IL-6却诱导心肌细胞再生，这使我们对IL-6的认识更加模糊。最后，有几种选择可以增加化疗期间的心脏保护作用，如果我们能够克服这些限制，通过使用几种机制来确认心脏保护趋化因子的有效性以及它们的激活，我们将突破化疗诱导的心脏毒性的困难。(c)2018爱思唯尔B. V.保留所有权利。
Background: Cardiotoxicity is one of the most important side effects of chemotherapy and its management save myocardium from injury and its consequences.Aim: In this review we discuss cardioprotective chemokines and cardioprotective mechanisms and pathways that induce cardioprotection through cardioprotective chemokines.Method: We searched English literature articles in Google scholar and PubMed from "1990 to 2018" through using the terms "Cardioprotection; Cardioprotective Chemokine; Chemotherapy Induced Cardiotoxicity; Cardiomyocytes; Cytokine".Discussion: The routine cardioprotective strategies during chemotherapy such as angiotensin-converting enzyme inhibitors and beta-blockers have cardioprotective effects. Cardioprotective mechanisms and strategies can offer the oncologist several methods to protect the cardiac system through using efficient cardioprotective agents. Chemokines such as SDF-1a, IL-6, IL-8, IL-12 and G-CSF are cardioprotective chemokines. Accelerating the cardioprotection through inducing cardioprotective chemokines production can be useful in chemotherapy.Conclusion: Stimulating the production of cardioprotective chemokines through the pathways which induce the production of cardioprotective chemokines can work strongly beside the beta-blockers and ACE inhibitors. The ambiguous point in cardioprotective pathways is that JAK2/STAT3 pathway which is linked to IL-6 production pathway, which induce intracellular adhesion molecule-1 in the area of the ischemia in myocardium and this process is not benefit in cardioprotection however IL-6 induce cardiomyocytes regeneration so it enhance our dull vision about IL-6. Finally there are several choices which can increase cardioprotection during the chemotherapy and if we overcome the boundaries in confirming the efficiency of cardioprotective chemokines and the activation of them through using several mechanisms we will break through the difficulties over chemotherapy-induced cardiotoxicity. (c) 2018 Elsevier B.V. All rights reserved.