Quantitative study of ageing epiglottal taste buds in humans
Quantitative study of ageing epiglottal taste buds in humans
复制标题
DOI：
10.1111/j.1741-2358.2007.00165.x
复制
发表时间：
2007-09-01
期刊：
影响因子：
2
通讯作者：
Kikuchi, Masayoshi
中科院分区：
文献类型：
--
作者：
Kano, Mitsuhiro;Shimizu, Yoshinaka;Kikuchi, Masayoshi
目的：应用组织形态计量学方法，对237例(男138例，女99例)会厌口部和喉部组织进行组织学观察和味蕾密度测量。病例分为两个年龄组：青年组67例，年龄10-39岁；老年组170例，年龄70-98岁。结果：老年组喉面味蕾平均密度明显降低。大多数味蕾出现在喉面的上高度水平，上面覆盖着薄而扁平的复层鳞状上皮。覆盖的上皮显示口腔表面有发达的上皮脊，没有味蕾。这些结果提示味蕾的存在与被覆上皮的厚度有关。结论：老年人会厌内存在味蕾。此外，还阐明了这些味蕾随着年龄的增长而减少的原因。
Objectives: This investigation aimed to demonstrate age-related changes of taste buds on the human epiglottis using histomorphometrical analysis.Methods: Histological observation and measurement of taste bud density were performed on oral and laryngeal surfaces of 237 human epiglottises (138 male and 99 females). The cases were divided into two age groups: 67 cases in the younger group, for subjects aged 10-39 years and 170 cases in the older group, for those aged 70-98 years. Each epiglottis was investigated at the upper and middle height levels.Results: The mean density of taste buds significantly decreased on the laryngeal surfaces in the older group. Most taste buds were present in the upper height level on the laryngeal surfaces which were covered with thin and flat stratified squamous epithelium. The covering epithelium revealed developed epithelial ridges on the oral surfaces without taste buds. These results suggest a relationship between the existence of taste buds and the thickness of the covering epithelium.Conclusions: The presence of taste buds in the epiglottises of elderly people was demonstrated. In addition, the decrease of these taste buds with advancing age was clarified.