Do better executive functions buffer the effect of current parental depression on adolescent depressive symptoms?
Do better executive functions buffer the effect of current parental depression on adolescent depressive symptoms?
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DOI：
10.1016/j.jad.2016.03.049
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发表时间：
2016-07-15
影响因子：
6.6
通讯作者：
Rice F
中科院分区：
文献类型：
--
作者：
Davidovich S;Collishaw S;Thapar AK;Harold G;Thapar A;Rice F
有重度抑郁症（MDD）病史的父母的后代，特别是那些暴露于当前父母抑郁症发作的后代，被发现自己患抑郁症的风险增加。暴露于当前的父母抑郁发作也降低了高风险或抑郁的青少年干预的有效性。这突出表明，需要确定保护因素的青少年暴露于当前的父母抑郁发作。执行功能是一种重要的认知资源，涉及调节情绪和思想以及科普压力事件的能力。本研究探讨了缓冲作用的两个组成部分的执行功能，抑制控制和心理灵活性，在当前的父母发作的抑郁症和青少年抑郁症状之间的关联。一个高风险的样本288青少年子女的父母与复发性重性抑郁症完成了情感去/不去和语言流畅性任务。父母和青少年接受了精神病学访谈。在父母中存在当前父母抑郁发作的情况下，在控制年龄，性别和智商后，具有更好的抑制控制和心理灵活性的青少年的抑郁症状较少。参与者是抑郁父母的后代，目前尚不清楚这里观察到的执行功能的保护作用是否会推广到其他人群。执行功能可以防止青少年抑郁症的父母抑郁发作的存在。它可能是有益的目标执行功能的预防计划，为个人在高风险的抑郁症。执行功能（EF）是否可以预防高危青年的抑郁症？参与者是患有复发性MDD的父母及其青少年后代。暴露于当前父母发作的青少年有更多的抑郁症状。高EF作为一种缓冲青少年暴露于当前的父母发作。在高危人群的干预中针对EF可能是有益的。
Offspring of parents with a history of major depressive disorder (MDD) and especially those exposed to a current episode of parental depression have been found to be at increased risk for developing depression themselves. Exposure to a current parental depressive episode also reduces the efficacy of interventions in high risk or depressed adolescents. This highlights the need to identify protective factors for adolescents exposed to a current parental depressive episode. Executive functions serve as an important cognitive resource, involved in the ability to regulate mood and thoughts and cope with stressful events. This study examined the buffering role of two components of executive functioning, inhibitory control and mental flexibility, in the association between a current parental episode of MDD and adolescent depressive symptoms. A high-risk sample of 288 adolescent offspring of parents with recurrent major depressive disorder completed an Affective Go/No Go and a Verbal Fluency task. Parents and adolescents underwent psychiatric interviews. In the presence of a current parental depressive episode in the parent, adolescents with better inhibitory control and mental flexibility had fewer depressive symptoms after controlling for age, gender and IQ. Participants were the offspring of depressed parents and it is not clear whether the protective effects of executive functioning observed here would generalise to other populations. Executive functions may protect against adolescent depression in the presence of a parental depressive episode. It may be beneficial to target executive functions in preventive programs for individuals at high-risk for depression. Do executive functions (EF) protect against depression in high-risk youth? Participants were parents with recurrent MDD and their adolescent offspring. Adolescents exposed to a current parental episode had more depressive symptoms. High EF served as a buffer for adolescents exposed to a current parental episode. Targeting EF in interventions for high risk groups may be beneficial.