Optical technologies for intraoperative neurosurgical guidance.
Optical technologies for intraoperative neurosurgical guidance.
复制标题
用于术中神经外科指导的光学技术。
DOI：
10.3171/2015.12.focus15550
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发表时间：
2016-03
影响因子：
4.1
通讯作者：
Golby A
中科院分区：
文献类型：
--
作者：
Valdés PA;Roberts DW;Lu FK;Golby A
生物医学光学是介于光学工程、生物物理学、计算机科学、医学、生物学和化学之间的一个广泛的交叉学科领域，它帮助我们了解光与组织的相互作用，从而创造出在医学上具有诊断和治疗价值的应用。近年来，生物医学光学工具和原理的应用在神经外科领域有了显著的科学和临床复苏。这在很大程度上是由于荧光引导的脑肿瘤手术的工作，导致报告在最大限度地提高大体全切除率方面有显着改善。多种额外的光学技术已经在临床上实施，包括漫反射光谱和成像，光学相干层析成像，拉曼光谱和成像，以及先进的定量方法，包括定量荧光和寿命成像。在这里，我们提出了一个临床相关的和技术知情的概述和讨论一些主要的临床实施光学技术作为术中的指导工具在神经外科。
Biomedical optics is a broadly interdisciplinary field at the interface of optical engineering, biophysics, computer science, medicine, biology, and chemistry, helping us understand light–tissue interactions to create applications with diagnostic and therapeutic value in medicine. Implementation of biomedical optics tools and principles has had a notable scientific and clinical resurgence in recent years in the neurosurgical community. This is in great part due to work in fluorescence-guided surgery of brain tumors leading to reports of significant improvement in maximizing the rates of gross-total resection. Multiple additional optical technologies have been implemented clinically, including diffuse reflectance spectroscopy and imaging, optical coherence tomography, Raman spectroscopy and imaging, and advanced quantitative methods, including quantitative fluorescence and lifetime imaging. Here we present a clinically relevant and technologically informed overview and discussion of some of the major clinical implementations of optical technologies as intraoperative guidance tools in neurosurgery.