Hepatitis C virus infection is a risk factor for tumor recurrence after resection of small hepatocellular carcinomas
Hepatitis C virus infection is a risk factor for tumor recurrence after resection of small hepatocellular carcinomas
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DOI：
10.1007/s00268-004-7320-9
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发表时间：
2004-08-01
影响因子：
2.6
通讯作者：
Lee, SD
中科院分区：
文献类型：
--
作者：
Huo, TI;Wu, JC;Lee, SD
肝细胞癌（HCC）与慢性B或丙型肝炎病毒（HBV、HCV）感染密切相关。手术切除后经常发生肿瘤复发，并可能对预后产生不利影响。本研究旨在探讨病毒性肝炎对肝癌切除术后复发的影响。共纳入248例因HCC接受根治性切除术的患者[HBV 165例，HCV 44例，HBV+HCV双重感染15例，非B非C（NBNC）24例]。根据基础肝炎的病因比较累积复发率，并根据肿瘤大小和其他临床病理参数分层。总共有116名患者（47%）在切除后17+/-11个月内肿瘤复发。四组患者（HBV、HCV、HBV+HCV、NBNC）的复发率无显著差异（p=0.248）。持续性肝炎在HCV组中更常见（所有参数的P 0.1）。总之，合并HCV感染的小肝癌患者切除后肿瘤复发的风险较高。
Hepatocellular carcinoma (HCC) is closely associated with chronic hepatitis B or C virus (HBV, HCV) infection. Tumor recurrence frequently occurs after surgical resection and may adversely affect the outcome. This study aimed to investigate the effect of viral hepatitis in association with HCC recurrence after resection. A total of 248 patients [HBV in 165, HCV in 44, dual HBV+HCV in 15, and non-B non-C (NBNC) in 24] who underwent curative resection for HCC were included. The cumulative recurrence rate was compared according to the etiology of the underlying hepatitis and was stratified by tumor size and other clinicopathologic parameters. Altogether, 116 patients (47%) had a tumor recurrence within 17+/-11 months after resection. No significant difference in recurrence was noted among the four groups of patients (HBV, HCV, HBV+HCV, NBNC) (p=0.248). Persistent hepatitis was more common in the HCV group (P0.1 for all parameters). In conclusion, patients with small HCCs and concurrent HCV infection are at a high risk of tumor recurrence after resection.