Noradrenergic neurotoxin, N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine hydrochloride (DSP-4), treatment eliminates estrogenic effects on song responsiveness in female zebra finches (Taeniopygia guttata).
Noradrenergic neurotoxin, N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine hydrochloride (DSP-4), treatment eliminates estrogenic effects on song responsiveness in female zebra finches (Taeniopygia guttata).
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去甲肾上腺素能神经毒素 N-(2-氯乙基)-N-乙基-2-溴苄胺盐酸盐 (DSP-4) 治疗可消除雌性斑胸草雀 (Taeniopygia guttata) 鸣叫反应能力的雌激素影响。
DOI：
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发表时间：
2008
影响因子：
1.9
通讯作者：
Diane M. Bogdan
中科院分区：
文献类型：
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作者：
A. Vyas;C. Harding;Joseph McGowan;Randall Snare;Diane M. Bogdan
雌性鸣禽用雄性的歌声作为择偶的重要标准。一些研究报告说，雌性鸣禽喜欢复杂的歌曲比其他歌曲类型。在最近的一项研究中，作者发现雌性斑胸草雀（Taeniopygia guttata）的歌声反应受到循环雌激素水平的强烈调节。雌激素的行为效应通常通过去甲肾上腺素（NE）介导。目前的研究管理去甲肾上腺素能神经毒素，N-（2-氯乙基）-N-乙基-2-溴苄胺盐酸盐（DSP-4）雌激素处理的雌性斑胸草雀的歌曲反应性的雌激素效应，调查是否通过NE介导。作者测试了成年雌性斑胸草雀在三种治疗条件下对三种声学上不同的歌曲类型-简单，长回合和复杂-的歌曲反应，未治疗，雌二醇治疗和雌二醇+ DSP-4治疗。女性只表现出差异的歌曲反应时，雌二醇单独治疗，反应更复杂的歌曲。DSP-4治疗消除了这种差异反应性。结果进行了讨论，从功能，神经化学和神经解剖学的研究表明，雌激素对歌曲处理的影响可能是由NE介导的证据。
Female songbirds use male songs as an important criterion for mate selection. Several studies have reported that female songbirds prefer complex songs to other song types. In a recent study, the authors found that song responsiveness in female zebra finches (Taeniopygia guttata) is strongly modulated by circulating estrogen levels. The behavioral effects of estrogen are often mediated via norepinephrine (NE). The current study administered the noradrenergic neurotoxin, N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine hydrochloride (DSP-4) to estradiol-treated female zebra finches to investigate if estrogenic effects on song responsiveness are mediated via NE. The authors tested song responsiveness of adult female zebra finches for three acoustically different song types--simple, long-bout, and complex--under three treatment conditions, untreated, estradiol-treated, and estradiol + DSP-4-treated. Females only showed differential song responsiveness when treated with estradiol alone, responding more to complex songs. DSP-4 treatment eliminated this differential responsiveness. The results are discussed in the light of evidence from functional, neurochemical, and neuroanatomical studies that suggest that estrogenic effects on song processing might be mediated by NE.