ASPIRIN AND CONGENITAL MALFORMATIONS
ASPIRIN AND CONGENITAL MALFORMATIONS
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阿司匹林与先天性畸形
DOI：
10.1016/s0140-6736(76)93025-7
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发表时间：
1976
期刊：
影响因子：
--
通讯作者：
S. Shapiro
中科院分区：
文献类型：
--
作者：
D. Slone;O. Heinonen;D. Kaufman;V. Siskind;RichardR. Monson;S. Shapiro
在美国的一组50282名孕妇及其后代中，35418名未接触阿司匹林的妇女、9736名中度接触阿司匹林的妇女和5128名在怀孕的前四个月大量接触阿司匹林的妇女的儿童的畸形率相似。在使用多变量分析控制了广泛的潜在混杂因素后，所有三个对照组中各种畸形类别的观察和预期数量相似。数据表明阿司匹林没有致畸性。
In a cohort of 50 282 gravidas and their offspring in the U.S.A., malformation rates were similar in the children of 35 418 women not exposed to aspirin, 9736 with intermediate exposure, and 5128 women heavily exposed during the first four lunar months of pregnancy. After controlling a wide range of potential confounding factors using multivariate analysis, the observed and expected numbers fora variety of malformation categories were similar in all three comparison groups. The data suggest that aspirin is not teratogenic.