Cicatrization of wounds. I. The relation between the size of a wound and the rate of its cicatrization.
Cicatrization of wounds. I. The relation between the size of a wound and the rate of its cicatrization.
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DOI：
10.1084/jem.24.5.429
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发表时间：
1916-11-01
影响因子：
15.3
通讯作者：
Hartmann, A
中科院分区：
文献类型：
--
作者：
Carrel, A;Hartmann, A
在1908年洛克菲勒研究所的实验过程中，研究了伤口的大小和愈合率之间存在的某些关系。实验表明，创面愈合初期的修复速度大于愈合结束时的修复速度，且不依赖于创面的年龄，而取决于创面的大小，与创面的大小成正比。因此，哺乳动物的皮肤L似乎是按照与斯帕兰扎尼发现的火蜥蜴相似的规律再生的。西班牙和勒布最近进行的实验表明，在豚鼠身上，伤口的大小和修复率之间也存在同样的关系。2以下实验的目的是寻找一种能够准确测量伤口大小的技术，确定代表愈合的曲线在形式上是否是几何的，并研究伤口大小与修复速度之间的关系，以及收缩和表皮形成过程的相对重要性。
In the course of experiments made in 1908 at The Rockefeller Institute certain relations existing between the size of a wound and the rate of cicatrization were studied. The experiments showed that the rate of repair was greater at the beginning than at the end of cicatrization, and depended not on the age of the wound but on its size, being directly proportional to it. l The skin of mammals seemed therefore to regenerate according to a law similar to that found by Spallanzani for salamanders. The experiments made lately by Spain and Loeb showed that in the guinea pig the same relation existed between the size of a wound and the rate of repair. 2 The object of the following experiments was to find a technique by which the size of a wound could be measured accurately, to ascertain whether the curve representing the cicatrization was geometric in form, and to study the relations between the size of a wound and the velocity of repair, as well as the relative importance of the processes of contraction and epidermization.EXPERIMENTAL.