Heart failure decreases nerve activity in the right atrial ganglionated plexus.
Heart failure decreases nerve activity in the right atrial ganglionated plexus.
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DOI：
10.1111/j.1540-8167.2011.02204.x
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发表时间：
2012-04
影响因子：
2.7
通讯作者：
Lin SF
中科院分区：
文献类型：
--
作者：
Shinohara T;Shen MJ;Han S;Maruyama M;Park HW;Fishbein MC;Shen C;Chen PS;Lin SF
我们验证了心力衰竭（HF）导致右心房神经节丛（RAGP）去神经支配导致窦房结功能障碍的假设。HF与窦房结功能障碍相关。然而，详细的机制仍不清楚。我们记录了7只步行犬在基线和起搏诱导HF后的RAGP、右星状神经节（SG）和右迷走神经的神经活动（NA）。我们还确定了RAGP刺激在离体正常和HF犬右心房（RA）的影响。HF患者SG和迷走神经的神经活动均显著高于基线水平。迷走神经和RAGP的1 min综合神经活动之间的关系呈线性正相关（第1组，n=4）或L形相关（第2组，n=3）。在所有犬中，当迷走神经NA与同时增加的RAGP-NA相关时，观察到心率降低。另一方面，当迷走神经NA与RAGP-NA增加无关时，心率不降低。HF组RAGP-NA显著降低（P<0.05）。刺激离体右心房的上级RAGP可显著降低正常心脏的窦性心率，但对HF心脏无影响。免疫组化染色显示HF RAGP中酪氨酸羟化酶和胆碱乙酰转移酶阳性神经组织的密度低于正常（分别为P<0.001和P=0.001）。RAGP神经活动对于迷走神经在窦性心率控制中平衡星状神经节至关重要。在心力衰竭中，RAGP去神经支配和RAGP神经活动减少导致窦房结功能障碍。
We tested the hypothesis that heart failure (HF) results in right atrial ganglionated plexus (RAGP) denervation which contributes to sinoatrial node dysfunction. HF is associated with sinoatrial node dysfunction. However, the detailed mechanisms remain unclear. We recorded nerve activity (NA) from the RAGP, right stellate ganglion (SG) and right vagal nerve in 7 ambulatory dogs at baseline and after pacing-induced HF. We also determined the effects of RAGP stimulation in isolated normal and HF canine right atria (RA). Nerve activities in both the SG and vagal were significantly higher in HF than at baseline. The relationship between 1-min integrated nerve activities of vagal and RAGP showed either a positive linear correlation (Group 1, n=4) or an L-shaped correlation (Group 2, n=3). In all dogs, a reduced heart rate was observed when vagal-NA was associated with simultaneously increased RAGP-NA. On the other hand, when vagal-NA was not associated with increased RAGP-NA, the heart rate was not reduced. The induction of HF significantly decreased RAGP-NA in all dogs (P<0.05). Stimulating the superior RAGP in isolated right atrium significantly reduced the sinus rate in normal but not the HF hearts. Immunohistochemical staining revealed lower densities of tyrosine hydroxylase and choline acetyltransferase -positive nerve tissues in HF RAGP than normal (P<0.001 and P=0.001, respectively). The RAGP nerve activity is essential for the vagal nerve to counterbalance the stellate ganglion in sinus rate control. In heart failure, RAGP denervation and decreased RAGP nerve activity contribute to the sinus node dysfunction.
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影响因子：
24
作者：
Ogawa, Masahiro;Zhou, Shengmei;Chen, Peng-Sheng
通讯作者：
Chen, Peng-Sheng
影响因子：
37.8
作者：
Sanders, P;Kistler, PM;Kalman, JM
通讯作者：
Kalman, JM
影响因子：
10.8
作者：
Lu, Zhibing;Scherlag, Benjamin J.;Po, Sunny S.
通讯作者：
Po, Sunny S.
DOI：
10.1111/j.1540-8167.2009.01613.x
发表时间：
2010-02-01
影响因子：
2.7
作者：
Mischke, Karl;Zarse, Markus;Schauerte, Patrick
通讯作者：
Schauerte, Patrick
影响因子：
24
作者：
Hou, Yinglong;Scherlag, Benjamin J.;Po, Sunny S.
通讯作者：
Po, Sunny S.