Hypomagnesaemia and risk for metabolic glucose disorders:: a 10-year follow-up study
Hypomagnesaemia and risk for metabolic glucose disorders:: a 10-year follow-up study
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DOI：
10.1111/j.1365-2362.2008.01957.x
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发表时间：
2008-06-01
影响因子：
5.5
通讯作者：
Wacher, N.
中科院分区：
文献类型：
--
作者：
Guerrero-Romero, F.;Rascon-Pacheco, R. A.;Wacher, N.
背景 尽管多项证据表明低镁血症是发生 2 型糖尿病的危险因素，但尚无关于低镁血症与发生空腹血糖受损 (IFG) 或糖耐量受损 (IGT) 风险之间关系的研究。我们的目的是检查血清镁水平与发生 IFG、IGT 和 2 型糖尿病的风险之间的关系。 材料和方法 1996 年至 1997 年间共有 1122 名受试者（20-65 岁）入组，约 10 年后对 817 名受试者进行了重新检查。新发 IFG（空腹血糖 5.6-7.0 mmol L-1）、IGT（负荷后 2 小时血糖 7.8-11.1 mmol L-1）和 2 型糖尿病是根据第二次检查时出现这些症状的受试者人数确定的，但没有证据表明他们在第一次检查时出现过这些症状。使用针对年龄、性别、糖尿病家族史、腰围和胰岛素抵抗指数的稳态模型评估进行调整的泊松回归模型计算新发代谢性葡萄糖障碍和糖尿病的相对风险（因变量）。血清镁水平 < 0.74 mmol L-1（自变量）定义为暴露组。结果 在基线时，420 人 (51.4%) 患有低镁血症。在 276 名 (33.8%) 个体中发现新发 IFG 和 IGT。 IFG、IGT 和 IFG + IGT 的相对风险分别为 1.11（95% 置信区间，0.5-5.1）、1.38（95% 置信区间，1.1-6.3）和 1.49（95% 置信区间，1.1-4.9）。 78 名 (9.5%) 个体中发现新发糖尿病（相对风险 2.54；95% 置信区间，1.1-4.1）。 结论 低镁血症与 IGT、IFG + IGT 和 2 型糖尿病的发生独立相关，但与 IFG 的发生无关。
Background Although several lines of evidence suggest that hypomagnesaemia is a risk factor for developing type 2 diabetes, there are no studies regarding the association between hypomagnesaemia and the risk for developing impaired fasting glucose (IFG) or impaired glucose tolerance (IGT). Our objective was to examine the association between serum magnesium levels and the risk for developing IFG, IGT and type 2 diabetes.Materials and methods A total of 1122 individuals (20-65 years of age) were enrolled between 1996 and 1997, and 817 individuals re-examined about 10 years later. New-onset IFG (5.6-7.0 mmol L-1 fasting glucose), IGT (7.8-11.1 mmol L-1 glucose 2-h postload), and type 2 diabetes were determined from the number of subjects who had these conditions at the second examination without evidence that they were present at the first one. The relative risk of new-onset metabolic glucose disorders and diabetes (dependent variables) was computed using Poisson regression model adjusted for age, sex, family history of diabetes, waist circumference and homeostasis model assessment for insulin resistance index. Serum magnesium levels of < 0.74 mmol L-1 (independent variable) defined the exposed group.Results At baseline, 420 (51.4%) individuals had hypomagnesaemia. New-onset IFG and IGT was identified in 276 (33.8%) individuals. The relative risk for IFG, IGT and IFG + IGT was 1.11 (95% confidence interval, 0.5-5.1), 1.38 (95% confidence interval, 1.1-6.3) and 1.49 (95% confidence interval, 1.1-4.9), respectively. New-onset diabetes was identified in 78 (9.5%) individuals (relative risk 2.54; 95% confidence interval, 1.1-4.1).Conclusions Hypomagnesaemia is independently associated with the development of IGT, IFG + IGT and type 2 diabetes, but not with the development of IFG.