THE GENERATION OF IMPULSES IN MOTONEURONES
THE GENERATION OF IMPULSES IN MOTONEURONES
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DOI：
10.1113/jphysiol.1957.sp005888
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发表时间：
1957-01-01
影响因子：
5.5
通讯作者：
ECCLES, JC
中科院分区：
文献类型：
--
作者：
COOMBS, JS;CURTIS, DR;ECCLES, JC
用突触刺激或经细胞内电极施加去极化电流的方法，使麻醉猫的运动神经元放电，记录在前根细丝中。这种放电总是与运动神经元起始段的锋电位（IS锋电位）有关，但与体突锋电位（SD锋电位）无关。此外，冲动出现在前根如此之快，发病后的IS尖峰，它必须已启动要么由最早的部分IS尖峰，甚至之前的初级反应的第一个节点的有髓轴突。当考虑到调节时，由突触作用或直接由外加电流产生的去极化在产生运动神经元尖峰上似乎是等效的。对于相对未被微电极损伤的运动神经元，起始段的阈值去极化范围为5-18 mv，平均为10 mv，而对于胞体-树突膜，阈值去极化范围为20-37 mv。这些发现的运动神经元的功能的关系进行了讨论。
By means of synaptic stimula-tion or by applying a depolarizing current through an intracellular electrode, motoneurones of anesthetized cats were caused to discharge impulses which were recorded in ventral root filaments. This dis-charge was always associated with a spike in the initial segment of the motoneurone (the IS spike), but was quite independent of the somadendrite spike (the SD spike). Also, the impulse appeared in the ventral root so quickly after the onset of the IS spike that it must have been initiated either by the earliest portion of the IS spike or even just before by a primary response of the 1st node of the medullated axon. When allowance is made for accommodation, it appears that depolarizations produced by synaptic action or directly by applied currents are equipotent in generating motoneuronal spikes. The threshold depolarization for the initial segment varied from 5-18 mv, with a mean of 10 mv, for moto-neurones relatively undamaged by the micro-electrode, while for the soma-dendritic membrane the range was 20-37 mv. The relationship of these findings to the functioning of the motoneurone is discussed.