Hippocampal sympathetic ingrowth and cholinergic denervation alter hippocampal muscarinic cholinergic receptors.
Hippocampal sympathetic ingrowth and cholinergic denervation alter hippocampal muscarinic cholinergic receptors.
复制标题
海马交感神经向内生长和胆碱能去神经改变海马毒蕈碱胆碱能受体。
DOI：
10.1002/hipo.450040210
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发表时间：
1994
期刊：
影响因子：
3.5
通讯作者：
Parsons,DS
中科院分区：
文献类型：
--
作者：
Harrell,LE;Ayyagari,V;Peagler,A;Parsons,DS
内侧隔（MS）损伤引起的海马胆碱能去神经支配导致源自上级颈神经节的外周交感神经纤维长入海马。为了确定海马交感神经向内生长（HSI）的影响，在MS损伤后4周，在背侧和腹侧海马中评估[3 H]-QNB（L-奎宁环基[benzilic-4，4（n）] benzilate）结合。在背侧海马中，发现HSI显著增加[3 H]-QNB结合位点的数量（Bmax），并使MS病变加神经节切除术动物中发现的亲和力降低正常化（i.例如，无向内生长）。在腹侧海马，HSI被发现正常化的结合位点的数量增加，并在没有向内生长的MS病变的动物中发现的亲和力降低。在用假MS病变进行神经节切除术的动物中，未发现对Kdor Bmax的影响。这些结果表明，HSI可引起海马M胆碱能受体的变化。© 1994 Wiley‐利斯公司
Cholinergic denervation of the hippocampus by medial septal (MS) lesions results in the ingrowth of peripheral sympathetic fibers, originating from the superior cervical ganglia, into the hippocampus. To determine the effect of hippocampal sympathetic ingrowth (HSI) [3H]‐QNB (L‐quinuclidinyl [benzilic‐4, 4(n)] benzilate) binding was assessed in the dorsal and ventral hippocampus four weeks after MS lesions. In dorsal hippocampus, HSI was found to signignificantly increase the number (Bmax) of [3H]‐QNB binding sites and to normalize the decrease in affinity found in animals with MS lesions plus ganglionectomy (i. e., no ingrowth). In ventral hippocampus, HSI was found to normalize the increased number of binding sites and decreased affinity found in animals with MS lesions without ingrowth. No effect on either Kdor Bmaxwas found in animals that had undergone ganglionectomy with sham MS lesions. These results suggest that HSI can induce changes in hippocampal muscarinic cholinergic receptors. © 1994 Wiley‐Liss, Inc.