IL-10, T cell exhaustion and viral persistence
IL-10, T cell exhaustion and viral persistence
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DOI：
10.1016/j.tim.2007.02.006
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发表时间：
2007-04-01
影响因子：
15.9
通讯作者：
Wherry, E. John
中科院分区：
文献类型：
--
作者：
Blackburn, Shawn D.;Wherry, E. John
病毒感染可能有两种结果之一：控制病毒复制和急性感染或病毒持续存在和慢性感染。很明显，病原体和宿主的特性都影响病毒感染的急性和慢性结果。然而，对宿主免疫应答中有利于免疫抑制和病毒持续存在的早期事件仍然知之甚少。使用急性与慢性淋巴细胞性脉络丛脑膜炎病毒（LCMV）感染的良好表征的小鼠模型，两个研究小组最近确定了白细胞介素-10（IL-10）/IL-10 R通路作为急性与慢性感染的关键调节因子。IL-10 R的阻断将慢性LCMV感染转化为快速控制的急性病毒感染，并防止记忆T细胞的功能衰竭。对IL-10在慢性感染建立中的作用的这些见解可能在人类感染病原体如HIV、丙型肝炎病毒（HCV）和B肝炎病毒（HBV）期间带来新的治疗机会。
Viral infections can have one of two outcomes: control of viral replication and acute infection or viral persistence and chronic infection. It is clear that both pathogen and host characteristics influence the acute versus chronic outcome of viral infection. The early events in the host immune response that favor immunosuppression and viral persistence, however, have remained poorly understood. Using the well-characterized mouse model of acute versus chronic lymphocytic choriomeningitis virus (LCMV) infection, two groups have recently identified the interleukin-10 (IL-10)/IL-10R pathway as a key regulator of acute versus chronic infection. Blockade of IL-10R converted a chronic LCMV infection into a rapidly controlled acute viral infection and prevented the functional exhaustion of memory T cells. These insights into the role of IL-10 in the establishment of chronic infection could lead to new therapeutic opportunities during human infections with pathogens such as HIV, hepatitis C virus (HCV) and hepatitis B virus (HBV).