Comparison of Bayesian penalized likelihood reconstruction versus OS-EM for characterization of small pulmonary nodules in oncologic PET/CT
Comparison of Bayesian penalized likelihood reconstruction versus OS-EM for characterization of small pulmonary nodules in oncologic PET/CT
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DOI：
10.1007/s12149-017-1192-1
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发表时间：
2017-10-01
影响因子：
2.6
通讯作者：
Borges-Neto, Salvador
中科院分区：
文献类型：
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作者：
Howard, Brandon A.;Morgan, Rustain;Borges-Neto, Salvador
目的 确定最近引入的贝叶斯惩罚似然 PET 重建 (Q.Clear) 相对于有序子集期望最大化 (OS-EM) 是否会增加接近 PET 分辨率极限的小肺部结节的视觉显着性和 SUVmax。 方法 在这项机构审查委员会批准且符合 HIPAA 的研究中，在五环 GE 上进行了 29 次 FDG PET/CT 扫描 Discovery IQ 被回顾性地选择用于放射科医生报告中描述为“太小而无法表征”的肺结节，或肺癌高风险患者的小肺结节。评估了 32 个肺结节，平均 CT 直径为 8 毫米（范围 2-18）。使用 OS-EM 和 Q.Clear 重建 PET 图像，噪声罚分强度 beta 值分别为 150、250 和 350。由三位读者按 3 分制对病变视觉显着性进行评分，并记录病变 SUVmax 以及背景肝脏和血池 SUVmean 和 SUVstdev。通过线性混合模型与修改后的Bonferroni事后检验进行比较；显着性截止值为 p < 0.05。 结果 Q. 与 beta = 150 (p < 0.01) 时的 OS-EM 相比，病灶视觉清晰度明显改善，但 250 或 350 则不然。与 beta = 150 和 250 (p < 0.01) 时的 OS-EM 相比，病灶 SUVmax 有所增加 (p < 0.01)，但不是 350。结论8 毫米 PET 与我们的标准非飞行时间 OS-EM 重建相比，Q.Clear 的全宽半最大值显着增加了病变视觉显着性和 SUVmax，但仅具有低噪声惩罚。 Q. 当主要关注肺部小结节的评估时，β = 150 的 Clear 可能会更有利。
Objective To determine whether the recently introduced Bayesian penalized likelihood PET reconstruction (Q.Clear) increases the visual conspicuity and SUVmax of small pulmonary nodules near the PET resolution limit, relative to ordered subset expectation maximization (OS-EM).Methods In this institutional review board-approved and HIPAA-compliant study, 29 FDG PET/CT scans performed on a five-ring GE Discovery IQ were retrospectively selected for pulmonary nodules described in the radiologist's report as "too small to characterize", or small lung nodules in patients at high risk for lung cancer. Thirty-two pulmonary nodules were assessed, with mean CT diameter of 8 mm (range 2-18). PET images were reconstructed with OS-EM and Q.Clear with noise penalty strength beta values of 150, 250, and 350. Lesion visual conspicuity was scored by three readers on a 3-point scale, and lesion SUVmax and background liver and blood pool SUVmean and SUVstdev were recorded. Comparison was made by linear mixed model with modified Bonferroni post hoc testing; significance cutoff was p < 0.05.Results Q.Clear improved lesion visual conspicuity compared to OS-EM at beta = 150 (p < 0.01), but not 250 or 350. Lesion SUVmax was increased compared to OS-EM at beta = 150 and 250 (p < 0.01), but not 350.Conclusion In a cohort of small pulmonary nodules with size near an 8 mm PET full-width half maximum, Q.Clear significantly increased lesion visual conspicuity and SUVmax compared to our standard non- time-of-flight OS-EM reconstruction, but only with low noise penalization. Q.Clear with beta = 150 may be advantageous when evaluation of small pulmonary nodules is of primary concern.