The ames dwarf gene is required for Pit-1 gene activation
The ames dwarf gene is required for Pit-1 gene activation
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DOI：
10.1006/dbio.1995.8040
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发表时间：
1995-12-01
影响因子：
2.7
通讯作者：
Rosenfeld, MG
中科院分区：
文献类型：
--
作者：
Andersen, B;Pearse, RV;Rosenfeld, MG
组织特异性POU结构域转录因子Pit-1是哺乳动物脑下垂体前叶三种细胞类型的表型指定所必需的：促生长激素、促甲状腺激素和促乳素。在Snell和Jackson Dwarf(Dw)小鼠中首次描述的Pit-1基因突变，由于缺乏这三种细胞类型而导致垂体腺发育不良，以及由于甲状腺刺激激素和生长激素缺乏而分别导致甲状腺功能减退和侏儒症。Ames侏儒(DF)表现出与Pit-1突变小鼠相同的表型，但该缺陷基因被定位在小鼠11号染色体上的一个座位上，与位于小鼠6号染色体上的Pit-1基因不同。我们的研究表明，Ames侏儒缺乏Pit-1基因的初始激活。这表明，DF基因是激活Pit-1基因所必需的，并为脑下垂体前叶细胞承诺所需的组织特异性因子的分级提供了证据。(C)1995年学术出版社。
The tissue-specific POU domain transcription factor Pit-1 is required for phenotypic specification of three cell types in the anterior pituitary gland of mammals: somatotropes, thyrotropes, and lactotropes. Mutations in the Pit-1 gene, as first described in Snell and Jackson dwarf (dw) mice, led to pituitary hypoplasia due to lack of these three cell types, as well as hypothyroidism and dwarfism because of deficiency of thyroid-stimulating hormone and growth hormone, respectively. The Ames dwarf (df) exhibits a phenotype identical to that of Pit-1-mutated mice but the defective gene has been mapped to a locus on mouse chromosome 11, distinct from the Pit-1 gene located on mouse chromosome 6. Our studies indicate that initial activation of the Pit-1 gene is deficient in the Ames dwarf. This suggests that the df gene is required for activation of the Pit-1 gene and provides evidence for a hierarchy of tissue-specific factors required for cellular commitment in the anterior pituitary gland. (C) 1995 Academic Press, Inc.