Genetical implications of the structure of deoxyribonucleic acid. 1953.
Genetical implications of the structure of deoxyribonucleic acid. 1953.
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DOI：
10.1001/jama.1993.03500150079031
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发表时间：
1993-04
期刊：
影响因子：
--
通讯作者：
J. Watson;F. Crick
中科院分区：
文献类型：
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作者：
J. Watson;F. Crick
脱氧核糖核酸(DNA)在活细胞中的重要性是毋庸置疑的。它存在于所有分裂的细胞中，即使不是全部，也主要存在于细胞核中，是染色体的重要组成部分。许多证据表明，它是染色体遗传专一性的一部分(如果不是全部)的携带者，因此也是基因本身的携带者。然而，到目前为止，还没有证据表明它可能会执行遗传物质所需的基本操作，即精确的自我复制。我们最近提出了一种脱氧核糖核酸盐的结构，如果正确的话，立即提出了一种自我复制的机制。伦敦国王学院的工作人员同时获得并提交的X射线证据对我们的结构提供了定性支持，与之前提出的所有结构3都不相容。尽管这一结构不会
THE importance of deoxyribonucleic acid (DNA) within living cells is undisputed. It is found in all dividing cells, largely if not entirely in the nucleus, where it is an essential constituent of the chromosomes. Many lines of evidence indicate that it is the carrier of a part of (if not all) the genetic specificity of the chromosomes and thus of the gene itself. Until now, however, no evidence has been presented to show how it might carry out the essential operation required of a genetic material, that of exact self-duplication. We have recently proposed a structure1for the salt of deoxyribonucleic acid which, if correct, immediately suggests a mechanism for its self-duplication. X-ray evidence obtained by the workers at King's College, London2, and presented at the same time, gives qualitative support to our structure and is incompatible with all previously proposed structures3. Though the structure will not