Technique for heterotopic pig heart xenotransplantation in primates
Technique for heterotopic pig heart xenotransplantation in primates
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DOI：
10.1016/s0003-4975(99)00488-9
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发表时间：
1999-07-01
影响因子：
4.6
通讯作者：
Naficy, S
中科院分区：
文献类型：
--
作者：
Adams, DH;Chen, RH;Naficy, S
灵长类动物是研究心脏移植后人体免疫反应的常用模型。本报告描述了我们在灵长类受体异位腹部移植猪心的经验。腹部移植的耐受性好得令人惊讶，我们发现这种方法在供受者大小不匹配的情况下特别有用。植入式监测系统的持续监测有助于评估清醒受者的移植物存活能力；进行性移植物心动过缓和QRS波幅降低是移植物随后失败的预测因素。(C)1999年，由胸外科医生学会颁发。
The primate is a commonly utilized model for the human immune response after heart transplantation. This report describes our experience with heterotopic abdominal transplantation of porcine hearts into primate recipients. Abdominal graft placement was surprisingly well tolerated, and we found this approach to be particularly useful in the setting of significant donor-recipient size mismatch. Continuous monitoring with an implantable monitoring system facilitated assessment of graft viability in awake recipients; progressive graft bradycardia and decreasing QRS amplitude were predictive of ensuing graft failure. (C) 1999 by The Society of Thoracic Surgeons.