Genetic polymorphisms of NAT2 and risk of acute myeloid leukemia: A case-control study
Genetic polymorphisms of NAT2 and risk of acute myeloid leukemia: A case-control study
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DOI：
10.1097/md.0000000000007499
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发表时间：
2017-10-01
期刊：
影响因子：
1.6
通讯作者：
Chen, Jieping
中科院分区：
文献类型：
--
作者：
Zou, Yunding;Dong, Song;Chen, Jieping
为探讨N-乙酰转移酶2（NAT 2）基因多态性与中国汉族人群急性髓细胞白血病（AML）的关系，采用病例对照研究方法，对98例AML患者和112名健康对照进行研究。采用直接测序法对NAT 2基因2多态性rs 1799930和rs 1799931进行基因分型。采用卡方检验比较各组间基因型和等位基因分布差异。结果表明，AML患者rs 1799931 GA基因型与对照组相比呈显著下降趋势，而祖先GG基因型频率在病例中增加，提示NAT 2基因rs 1799931多态性与AML发病风险降低相关，可能是AML发生的保护性因素。
Our purpose was to investigate the possible associations between N-acetyltransferase-2 (NAT2) gene polymorphisms and the risk of acute myeloid leukemia (AML) in Chinese Han population.A case-control study was conducted including 98 AML cases and 112 healthy controls. NAT2 gene 2 polymorphisms rs1799930 and rs1799931 were genotyped using direct sequencing. Chi-square test was performed to compare the genotype and allele distribution differences between groups. Odds ratio (OR) with 95% confidence interval (CI) was calculated to estimate the association between NAT2 gene polymorphisms and AML onset.A remarkable decrease trend of rs1799931 GA genotype was detected in AML patients compared with controls, whereas the ancestral GG genotype frequency increased in cases (P.05).Our findings suggested that NAT2 gene polymorphism rs1799931 was associated with decreased risk of AML and was likely to be a protective factor against AML development.