Poorer physical fitness is associated with reduced structural brain integrity in heart failure
Poorer physical fitness is associated with reduced structural brain integrity in heart failure
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DOI：
10.1016/j.jns.2013.02.015
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发表时间：
2013-05-15
影响因子：
4.4
通讯作者：
Gunstad, John
中科院分区：
文献类型：
--
作者：
Alosco, Michael L.;Brickman, Adam M.;Gunstad, John
目的：身体素质是健康成人大脑结构和功能完整性的重要相关因素。在心力衰竭（HF）患者中，身体素质差可能导致认知功能障碍，我们研究了身体素质对心力衰竭患者脑结构完整性的独特贡献。方法：69例HF患者行改良迷你精神状态检查（3MS），并行脑磁共振成像。所有的参与者都完成了2分钟的步幅测试（2MST），这是一项对身体健康的简短测量。我们研究了认知能力、身体健康和大脑整体完整性的三个指标之间的关系：总皮层灰质体积、总白质体积和全脑皮层厚度。结果：调整人口统计学特征、医学变量（如左心室射血分数）和颅内容量的回归分析显示，2MST功能下降与灰质体积减少和皮层变薄有关
Objective: Physical fitness is an important correlate of structural and functional integrity of the brain in healthy adults. In heart failure (HF) patients, poor physical fitness may contribute to cognitive dysfunction and we examined the unique contribution of physical fitness to brain structural integrity among patients with HF.Methods: Sixty-nine HF patients performed the Modified Mini Mental State examination (3MS) and underwent brain magnetic resonance imaging. All participants completed the 2-minute step test (2MST), a brief measure of physical fitness. We examined the associations between cognitive performance, physical fitness, and three indices of global brain integrity: total cortical gray matter volume, total white matter volume, and whole brain cortical thickness.Results: Regression analyses adjusting for demographic characteristics, medical variables (e.g., left ventricular ejection fraction), and intracranial volume revealed reduced performance on the 2MST were associated with decreased gray matter volume and thinner cortex (p