CROSS-MODAL NEUROPLASTICITY IN THE BLIND MOLE-RAT SPALAX-EHRENBERGI - A WGA-HRP TRACING STUDY
CROSS-MODAL NEUROPLASTICITY IN THE BLIND MOLE-RAT SPALAX-EHRENBERGI - A WGA-HRP TRACING STUDY
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DOI：
10.1097/00001756-199412000-00072
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发表时间：
1994-12-20
期刊：
影响因子：
1.7
通讯作者：
WOLLBERG, Z
中科院分区：
文献类型：
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作者：
DORON, N;WOLLBERG, Z
Ehrenbergi是一种地下啮齿动物，眼睛极度退化，但有一个明显的背外侧膝状核(DLGN)，它同侧投射到一个相当大的纹状皮质。2-脱氧葡萄糖和电生理研究表明，这些区域被听觉输入强烈激活，我们在这里使用神经解剖学示踪剂WGA-HRP表明，视觉系统听觉输入的主要来源是下丘，它除了所有典型的听觉靶点外，还投射到dLGN。视觉丘脑-皮质通路因此处理听觉信息。这是第一个追踪和描述听觉补偿投射起源的自然失明哺乳动物。
SPALAX ehrenbergi is a subterranean rodent possessing extremely degenerated eyes but a distinguishable dorsal lateral geniculate nucleus (dLGN) which projects ipsilaterally to a fair sized striate cortex. 2-Deoxyglucose and electrophysiological studies have shown that these areas are vigorously activated by auditory input, We show here, using the neuroanatomical tracer WGA-HRP, that the major source of the auditory input to the visual system is the inferior colliculus that, in addition to all its typical auditory targets, also projects to the dLGN. The visual thalamo-cortical pathway thereupon processes auditory information. This is the first naturally blind mammal in which the origin of auditory compensatory projections have been traced and described.