Tinnitus and hyperacusis: Central noise, gain and variance.
Tinnitus and hyperacusis: Central noise, gain and variance.
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DOI：
10.1016/j.cophys.2020.10.009
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发表时间：
2020-12
影响因子：
2.5
通讯作者：
Zeng FG
中科院分区：
文献类型：
--
作者：
Zeng FG
Tinnitus is a phantom auditory sensation in the absence of external sounds, while hyperacusis is an atypical sensitivity to external sounds that leads them to be perceived as abnormally loud or even painful. Both conditions may reflect the brain’s over-compensation for reduced input from the ear. The present work differentiates between two compensation models: The additive central noise compensates for hearing loss and is likely to generate tinnitus, whereas the multiplicative central gain compensates for hidden hearing loss and is likely to generate hyperacusis. Importantly, both models predict increased variance in central representations of sounds, especially a nonlinear increase in variance by the central gain. The increased central variance limits the amount of central compensation and reduces temporal synchrony, which can explain the insufficient central gain reported in the literature. Future studies need to collect trial-by-trial firing variance data so that the present variance-based model can be falsified.
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SCANDINAVIAN AUDIOLOGY
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通讯作者：
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