Migraine is a risk factor for sudden sensorineural hearing loss: A nationwide population-based study
Migraine is a risk factor for sudden sensorineural hearing loss: A nationwide population-based study
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DOI：
10.1177/0333102412468671
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发表时间：
2013-01-01
期刊：
影响因子：
4.9
通讯作者：
Wang, Shuu-Jiun
中科院分区：
文献类型：
--
作者：
Chu, Chia-Huei;Liu, Chia-Jen;Wang, Shuu-Jiun
背景：特发性突发性感音神经性听力损失（SSNHL）的病理生理机制尚不清楚。很少有病例报告提出偏头痛和SSNHL之间可能存在联系。目的：本研究旨在通过一项全国性、基于人群的队列研究，探讨偏头痛患者特发性SSNHL的风险。方法：我们从2000年至2009年的台湾全民健康保险研究数据库（NHIRD）中筛选偏头痛患者。根据年龄、性别和合并症，每个偏头痛患者与四名随机选择的无偏头痛受试者相匹配。两组患者均被随访至2009年底。我们比较了两个队列中SSNHL的发病率，并确定了危险因素。结果：共有10,280名偏头痛患者和41,120名匹配的对照组入组，中位随访时间为5年。偏头痛组发生SSNHL的风险高于匹配组(81.6 vs 45.7 / 100000人-年，发病率比(IRR) = 1.8；95%置信区间（CI） 1.22-2.61, p = 0.002)。Cox比例风险分析显示，在偏头痛患者中，合并高血压与SSNHL的发生趋势相关（风险比(HR) = 1.92, 95% CI 0.97-3.79, p = 0.06）。结论：这项基于人群的研究表明，偏头痛与特发性SSNHL的风险增加有关，然而，这是一种罕见的疾病。
Background: The pathophysiology of idiopathic sudden sensorineural hearing loss (SSNHL) is poorly understood. Few case reports have proposed a possible link between migraine and SSNHL.Objectives: This study aimed to explore the risk of idiopathic SSNHL in patients with migraine in a nationwide, population-based cohort study.Methods: We identified patients with migraine from the Taiwan National Health Insurance Research Database (NHIRD) between 2000 and 2009. Each migraine patient was matched with four randomly selected subjects without migraine for age, sex, and comorbidities. Both cohorts were followed up until the end of 2009. We compared the incidence rates of SSNHL in the two cohorts and identified the risk factors.Results: A total of 10,280 migraine patients and 41,120 matched controls were enrolled with a median follow-up of five years. The migraine cohort had a greater risk of developing SSNHL than the matched cohort (81.6 vs. 45.7 per 100,000 person-years, incidence rate ratio (IRR) = 1.8; 95% confidence interval (CI) 1.22-2.61, p = 0.002). The Cox proportional hazards analysis revealed that among migraine subjects, comorbidity with hypertension was associated with a trend of developing SSNHL (hazard ratio (HR) = 1.92, 95% CI 0.97-3.79, p = 0.06).Conclusions: This population-based study demonstrates that migraine is associated with an increased risk of idiopathic SSNHL, which, however, is a rare condition.