Association of high-sensitivity C-reactive protein and odds of breast cancer by molecular subtype: analysis of the MEND study.
Association of high-sensitivity C-reactive protein and odds of breast cancer by molecular subtype: analysis of the MEND study.
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DOI：
10.18632/oncotarget.27991
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发表时间：
2021-06-22
期刊：
影响因子：
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通讯作者：
Akinyemiju T
中科院分区：
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作者：
Gupta A;Oyekunle T;Salako O;Daramola A;Alatise O;Ogun G;Adeniyi A;Deveaux A;Saraiya V;Hall A;Ayandipo O;Olajide T;Olasehinde O;Arowolo O;Adisa A;Afuwape O;Olusanya A;Adegoke A;Tollefsbol TO;Arnett D;Muehlbauer MJ;Newgard CB;H3 Africa Kidney Research Network;Akinyemiju T
尼日利亚乳腺癌 (BC) 的特点是具有不成比例的侵袭性分子亚型。 C 反应蛋白 (CRP) 与多种癌症的风险和侵袭性相关。我们根据分子亚型在尼日利亚女性中检查了高敏 CRP (hsCRP) 与 BC 几率的关联。在 296 名新诊断的 BC 病例和 259 名健康对照中，使用多变量逻辑回归模型来估计 hsCRP 与整体和分子亚型（Luminal A、Luminal B、HER2 富集和三阴性或 TNBC）的 BC 几率之间关联的调整优势比 (aOR) 和 95% 置信区间 (CI)。在 57% 的病例和 31% 的对照中观察到高 hsCRP（> 3 mg/L），在调整社会人口、生殖和临床变量后，与 BC 几率的 4 倍相关（aOR：4.43；95% CI：2.56，7.66）。无论绝经状态和体重指数 (BMI) 类别如何，这种关联都持续存在。高 hsCRP 与 TNBC（aOR：3.32；95% CI：1.07、10.35）、luminal ABC（aOR：4.03；95% CI：1.29、12.64）和富含 HER2 的 BC（aOR：6.27；95% CI：1.69）的几率增加相关。 23.25）。未来需要对该人群进行研究，以进一步评估 CRP 作为 BC 预测生物标志物的潜在作用。
Breast cancer (BC) in Nigeria is characterized by disproportionately aggressive molecular subtypes. C-reactive protein (CRP) is associated with risk and aggressiveness for several types of cancer. We examined the association of high-sensitivity CRP (hsCRP) with odds of BC by molecular subtype among Nigerian women. Among 296 newly diagnosed BC cases and 259 healthy controls, multivariable logistic regression models were used to estimate adjusted odds ratios (aOR) and 95% confidence intervals (CI) for the association between hsCRP and odds of BC overall and by molecular subtype (luminal A, luminal B, HER2-enriched and triple-negative or TNBC). High hsCRP (> 3 mg/L) was observed in 57% of cases and 31% of controls and was associated with 4 times the odds of BC (aOR: 4.43; 95% CI: 2.56, 7.66) after adjusting for socio-demographic, reproductive, and clinical variables. This association persisted regardless of menopausal status and body mass index (BMI) category. High hsCRP was associated with increased odds of TNBC (aOR: 3.32; 95% CI: 1.07, 10.35), luminal A BC (aOR: 4.03; 95% CI: 1.29, 12.64), and HER2-enriched BC (aOR: 6.27; 95% CI: 1.69, 23.25). Future studies are necessary in this population to further evaluate a potential role for CRP as a predictive biomarker for BC.