DNA Biosensors and Microarrays
DNA Biosensors and Microarrays
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DOI：
10.1002/chin.200817270
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发表时间：
2008-04
期刊：
影响因子：
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通讯作者：
Audrey Sassolas;B. Leca-Bouvier;L. Blum
中科院分区：
文献类型：
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作者：
Audrey Sassolas;B. Leca-Bouvier;L. Blum
DNA生物传感器和DNA微阵列的发展在过去几年中得到了巨大的增长，这一领域的大量科学出版物证明了这一点（图1）。重要的是要指出，有关DNA生物传感器的综述主要集中在电化学转导上。2r10描述DNA生物传感器的论文非常少，不仅包括电化学，而且包括光学和压电转换模式。[11]此外，这项工作还研究了DNA微阵列的最新进展。DNA探针的固定化和杂交检测已被大量报道。近年来，对基于DNA的诊断测试的兴趣一直在增长。允许DNA检测的系统的开发受到许多领域中的应用的激励：DNA诊断、基因分析、生物战剂的快速检测和法医应用。在分子水平上检测基因突变开辟了甚至在疾病的任何症状出现之前进行可靠诊断的可能性。
Development of DNA biosensors and DNA microarrays has increased tremendously over the past few years as demonstrated by the large number of scientific publications in this area (Figure 1).Recent progress in the development of DNA biosensors and microarrays is summarized in this review. It is important to point out that reviews dealing with DNA biosensors mainly focus on electrochemical transduction. 2r10 Very few papers have been written describing DNA biosensors including not only electrochemical but also optical and piezoelectric transduction modes. 11 Moreover, the recent evolution of DNA microarrays is also studied in this work. DNA probe immobilization and hybridization detection are largely reported. In recent years, the interest for DNA-based diagnostic tests has been growing. The development of systems allowing DNA detection is motivated by applications in many fields: DNA diagnostics, gene analysis, fast detection of biological warfare agents, and forensic applications. Detection of genetic mutations at the molecular level opens up the possibility of performing reliable diagnostics even before any symptom of a disease appears.