MULTIMODAL IMAGING OF DISEASE-ASSOCIATED PIGMENTARY CHANGES IN RETINITIS PIGMENTOSA.
MULTIMODAL IMAGING OF DISEASE-ASSOCIATED PIGMENTARY CHANGES IN RETINITIS PIGMENTOSA.
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DOI：
10.1097/iae.0000000000001256
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发表时间：
2016-12
期刊：
影响因子：
--
通讯作者：
Sparrow JR
中科院分区：
文献类型：
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作者：
Schuerch K;Marsiglia M;Lee W;Tsang SH;Sparrow JR
使用多种成像方式，我们评估了视网膜色素变性（RP）中与骨针形黑色素沉着相关的感光细胞和RPE的变化。在60例RP患者的队列中，研究了短波长自发荧光（SW-AF），近红外（NIR）-AF，近红外反射（NIR-R），光谱域光学相干断层扫描（SD-OCT）和彩色眼底图像。在SW-AF和NIR-AF图像中均可见中央AF环。骨针色素沉着在NIR-R中为无反射，在SW-AF和NIR-AF成像中为低自发荧光，在SD-OCT图像中表现为视网膜内高反射灶。在AF环外边界以外的区域中，在SD-OCT扫描中不存在感光体椭圆区（EZ）带，并且在SW-AF、NIR-AF和NIR-R图像中脉络膜血管的可见性指示RPE色素沉着减少。脉络膜可见性在接近骨针色素沉着周边区域的区域中最明显;此处RPE/Bruch膜变薄在SD-OCT扫描中变得明显。这些发现与RPE细胞响应于感光细胞变性而腾出其单层并迁移到视网膜内层的过程一致。剩余的RPE扩散，经历变薄，因此变得更少色素沉着。对于NIR-AF黑色素信号的缺失与骨针色素沉着的关系的解释尚未出现。
Using multiple imaging modalities we evaluated the changes in photoreceptor cells and RPE that are associated with bone spicule-shaped melanin pigmentation in retinitis pigmentosa (RP). In a cohort of 60 RP patients, short-wavelength autofluorescence (SW-AF), near-infrared (NIR)-AF, NIR-reflectance (NIR-R), spectral domain optical coherence tomography (SD-OCT) and color fundus images were studied. Central AF rings were visible in both SW-AF and NIR-AF images. Bone spicule pigmentation was non-reflective in NIR-R, hypoautofluorescent with SW-AF and NIR-AF imaging and presented as intraretinal hyperreflective foci in SD-OCT images. In areas beyond the AF ring outer border, the photoreceptor ellipsoid zone (EZ) band was absent in SD-OCT scans and the visibility of choroidal vessels in SW-AF, NIR-AF and NIR-R images was indicative of reduced RPE pigmentation. Choroidal visibility was most pronounced in the zone approaching peripheral areas of bone spicule pigmentation; here RPE/Bruch’s membrane thinning became apparent in SD-OCT scans. These findings are consistent with a process by which RPE cells vacate their monolayer and migrate into inner retina in response to photoreceptor cell degeneration. The remaining RPE spread, undergo thinning and consequently become less pigmented. An explanation for the absence of NIR-AF melanin signal in relation to bone spicule pigmentation is not forthcoming.