Stability of the acoustic startle response and its modulation in children with typical development and those with autism spectrum disorders: a one-year follow-up.
Stability of the acoustic startle response and its modulation in children with typical development and those with autism spectrum disorders: a one-year follow-up.
复制标题
具有典型发育的儿童和患有自闭症谱系障碍的儿童的声惊吓反应及其调节的稳定性：一年的随访。
DOI：
10.1002/aur.1710
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发表时间：
2017
期刊：
影响因子：
4.7
通讯作者：
Kamio Y.
中科院分区：
文献类型：
--
作者：
Takahashi H;Nakahachi T;Stickley A;Ishitobi M;Kamio Y.
听觉高反应性是一种常见的感官知觉异常，会中断自闭症谱系障碍（ASD）的行为适应。最近，在ASD儿童中报告了延长的声惊吓反应（ASR）潜伏期和对弱声刺激的高反应性。已知ASR及其调节的指标是用于成人群体中的转化研究的稳定生物学标记。然而，对这些指标在儿童中的稳定性知之甚少。因此，我们的研究目的是调查ASD和典型发育（TD）儿童的神经生理学ASR指标的稳定性。参与者包括12名ASD儿童和24名TD儿童。分析了以10 dB增量在65-105 dB处呈现的声刺激的平均惊吓幅度。还分析了平均峰值惊吓潜伏期（PSL）、习惯化的ASR调制和前脉冲抑制。在自基线起15.7 ± 5.1个月的随访期后检查这些惊吓指标。在基线和随访期间，与对照组相比，ASD儿童对65-85 dB的弱刺激的惊吓幅度显著更大，PSL更长。两个时期之间这些ASR指标的组内相关系数为0.499-0.705。两个时期的ASR指标无显著差异。我们的研究结果表明，ASD儿童对弱刺激的长时间PSL和更大的惊吓幅度可能是ASD的中等稳定的神经生理学指标。© 2016国际自闭症研究学会，Wiley Periodicals，Inc.Autism Res 2017，10：673-679。© 2016国际自闭症研究学会，Wiley Periodicals，Inc.
Auditory hyper‐reactivity is a common sensory–perceptual abnormality that interrupts behavioral adaptations in autism spectrum disorders (ASD). Recently, prolonged acoustic startle response (ASR) latency and hyper‐reactivity to weak acoustic stimuli were reported in children with ASD. Indexes of ASR and its modulation are known to be stable biological markers for translational research in the adult population. However, little is known about the stability of these indexes in children. Thus, the objective of our study was to investigate the stability of neurophysiological ASR indexes in children with ASD and typical development (TD). Participants included 12 children with ASD and 24 with TD. Mean startle magnitudes to acoustic stimuli presented at 65–105 dB in increments of 10 dB were analyzed. Average peak startle latency (PSL), ASR modulation of habituation, and prepulse inhibition were also analyzed. These startle measures were examined after a follow‐up period of 15.7 ± 5.1 months from baseline. At both baseline and in the follow‐up period, children with ASD had significantly greater startle magnitudes to weak stimuli of 65–85 dB and more prolonged PSL compared with controls. Intraclass correlation coefficients for these ASR measures between both periods were 0.499–0.705. None of the ASR measures differed significantly between the two periods. Our results suggest that prolonged PSL and greater startle magnitudes to weak stimuli in children with ASD might serve as moderately stable neurophysiological indexes of ASD.Autism Res2016. © 2016 International Society for Autism Research, Wiley Periodicals, Inc.Autism Res2017, 10: 673–679. © 2016 International Society for Autism Research, Wiley Periodicals, Inc.