Small extracellular vesicles: Yields, functionalization and applications in diabetic wound management
Small extracellular vesicles: Yields, functionalization and applications in diabetic wound management
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DOI：
10.1002/inmd.20230019
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发表时间：
2023-10
期刊：
影响因子：
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通讯作者：
Xi Liu;Qian Wei;Zijie Sun;Shengnan Cui;Xizi Wan;Zi-qiang Chu;Yikai Zhang;Weicheng Zhong
中科院分区：
文献类型：
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作者：
Xi Liu;Qian Wei;Zijie Sun;Shengnan Cui;Xizi Wan;Zi-qiang Chu;Yikai Zhang;Weicheng Zhong
糖尿病伤口给患者和社会带来了巨大的负担，皮肤修复细胞功能障碍阻碍了长期的愈合过程。细胞外小泡（Small extracellular vesicles，sEVs）作为细胞间通讯的重要媒介，在糖尿病创面修复中具有重要的治疗价值。然而，sEV的低产量和有限的生物功能极大地挑战了它们的大规模临床应用。本文简要介绍了sEVs的生物来源和细胞摄取，重点介绍了利用工程方法提高sEVs产量和优化sEVs功能的研究进展，并对工程化sEVs在糖尿病伤口治疗中的应用进行了综述。此外，还讨论了工程sEV临床转化过程中尚未解决的问题。这篇重要的综述旨在为工程sEV在糖尿病伤口管理中的未来应用提供有意义的指导。
Diabetic wounds have imposed a significant burden on both patients and society with prolonged healing processes hindered by dysfunctional skin repair cells. Small extracellular vesicles (sEVs), as the important media for intercellular communications, show promising therapeutic potential in treating diabetic wounds by restoring cellular functions. However, low yields and limited bio‐function of sEVs greatly challenge their large‐scale clinical use. Here, we briefly overview the biogenesis and cellular uptake of sEVs, emphasize current advances in improving the yields of sEVs and optimizing the function of sEVs with engineering approaches, and summarize the applications of engineered sEVs in diabetic wound treatment. Furthermore, the undissolved issues during the clinical transformation of engineered sEVs are also discussed. This critical review aims to provide meaningful guidance for future applications of engineered sEVs in the management of diabetic wounds.