In vivo bone lead measurements: a rapid monitoring method for cumulative lead exposure.
In vivo bone lead measurements: a rapid monitoring method for cumulative lead exposure.
复制标题
体内骨铅测量：累积铅暴露的快速监测方法。
DOI：
10.1002/ajim.4700090304
复制
发表时间：
1986
影响因子：
3.5
通讯作者：
Landrigan,PJ
中科院分区：
文献类型：
--
作者：
Wielopolski,L;Ellis,KJ;Vaswani,AN;Cohn,SH;Greenberg,A;Puschett,JB;Parkinson,DK;Fetterolf,DE;Landrigan,PJ
采用 X 射线荧光技术在体内无创地测量人骨（胫骨）中的铅浓度（μg/g 湿重）。 45 名长期接触工业的工人被发现平均骨铅含量为 52.9 微克/克湿重（0 至 198 微克/克）。除了骨铅含量外，还评估了血铅、通过 EDTA 螯合后尿铅排泄评估的身体铅负荷、锌原卟啉和未刺激的尿铅排泄。结果表明，胫骨铅含量的体内测量可以作为身体铅负荷的可接受的指标，并为铅筛查目的提供实用技术。 X 射线荧光结果与 Ca-EDTA 给药后铅排泄之间的相关系数为 0.69：p < 0.001。
Lead concentrations (μg/g wet weight) in human bone (tibia) were measured noninvasively in vivo employing an X‐ray fluorescence technique. Forty‐five workers who had been subjected to chronic industrial exposure were found to have a mean bone lead content of 52.9 μg/g wet weight (0 to 198 μg/g). In addition to bone lead content, blood lead, body burden of lead as assessed by urinary lead excretion after EDTA chelation, zinc protoporphyrin, and unstimulated urinary lead excretion were evaluated. The results suggest that the in vivo measurement of tibia lead content may serve as an acceptable indicator of body lead burden and provide a practical technique for lead screening purposes. The correlation coefficient between X‐ray fluorescence findings and lead excretion following Ca‐EDTA administration is 0.69: p < 0.001.