ODORANTS OF THE SAME ODOR CLASS ACTIVATE DIFFERENT 2ND MESSENGER PATHWAYS
ODORANTS OF THE SAME ODOR CLASS ACTIVATE DIFFERENT 2ND MESSENGER PATHWAYS
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DOI：
10.1093/chemse/16.1.19
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发表时间：
1991-02-01
期刊：
影响因子：
3.5
通讯作者：
BOEKHOFF, I
中科院分区：
文献类型：
--
作者：
BREER, H;BOEKHOFF, I
许多化学品具有相同的气味质量（水果，花卉，草本，腐烂）进行了测定，其潜力激活第二信使途径的纤毛制剂从大鼠嗅上皮细胞使用快速淬火流动程序。 结果发现，具有相似气味的化合物并不都激活相同的第二信使，而是诱导环磷酸腺苷或三磷酸肌醇的形成。 因此，替代反应级联可以被具有类似气味质量的化学品激活。
A number of chemicals with the same odor quality (fruity, floral, herbaceous, putrid) were assayed for their potential to activate second messenger pathways in cilia preparations from rat olfactory epithelia using a rapid-quench flow procedure. It was found that compounds with similar odor do not all activate the same second messenger but rather induced the formation of either cyclic adenosine monophosphate or inositol triphosphate. Thus, alternative reaction cascades can be activated by chemicals with a similar odor quality.