Histamine- and acetylcholine-induced changes in the permeability of the blood-brain barrier of normotensive and spontaneously hypertensive rats.
Histamine- and acetylcholine-induced changes in the permeability of the blood-brain barrier of normotensive and spontaneously hypertensive rats.
复制标题
组胺和乙酰胆碱诱导正常血压和自发性高血压大鼠血脑屏障通透性的变化。
DOI：
10.1016/0028-3908(83)90153-3
复制
发表时间：
1983
影响因子：
4.7
通讯作者：
Reddix,I
中科院分区：
文献类型：
--
作者：
Domer,FR;Boertje,SB;Bing,EG;Reddix,I
Wistar-Kyoto（WKY）和自发性高血压（SHR）大鼠分别给予生理盐水、组胺（1.25、2.5或5.0 μg/kg）或乙酰胆碱（1.0或2.0 μg/kg）。两种药物均引起剂量依赖性血压降低，在自发性高血压动物中降低幅度更大。血脑屏障的通透性用131 I标记的血清白蛋白（RISA）或99 mTc-高锝酸钠（TcO−4）测量。最低剂量的组胺引起正常血压大鼠血脑屏障对血清白蛋白的通透性降低，乙酰胆碱引起通透性增加。只有最大剂量的组胺增加了自发性高血压大鼠血脑屏障对血清白蛋白的通透性。所有剂量的组胺和乙酰胆碱增加了血脑屏障的渗透性，钠每technetate在正常大鼠和两个较低剂量的组胺增加了自发性高血压动物的渗透性。这提供了全身血压变化与血脑屏障通透性变化分离的另一个例子。
Wistar-Kyoto (WKY) and spontaneously hypertensive (SHR) rats were given saline, histamine (1.25, 2.5 or 5.0 μg/kg) or acetylcholine (1.0 or 2.0 μg/kg). Both agents caused a dose-dependent decrease in blood pressure which was greater in the spontaneously hypertensive animals. The permeability of the blood brain barrier was measured with131I-labelled serum albumin (RISA) or with99mTc-sodium pertechnetate (TcO−4). The lowest dose of histamine caused a decrease in permeability of the blood brain barrier to serum albumin in normotensive rats and acetylcholine caused an increase. Only the largest dose of histamine increased the permeability of the blood brain barrier to serum albumin in spontaneously hypertensive rats. All doses of histamine and acetylcholine increased the permeability of the blood-brain barrier to sodium per technetate in nomotensive rats and the two lower doses of histamine increased the permeability in spontaneously hypertensive animals. This provides another example of the dissociation of change in the systemic blood pressure and change in the permeability of the blood-brain barrier.