Human papillomavirus type 16 E6 variants and HLA class II alleles among Japanese women with cervical cancer
Human papillomavirus type 16 E6 variants and HLA class II alleles among Japanese women with cervical cancer
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DOI：
10.1002/ijc.11332
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发表时间：
2003-10-10
影响因子：
6.4
通讯作者：
Taketani, Y
中科院分区：
文献类型：
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作者：
Matsumoto, K;Yasugi, T;Taketani, Y
特定人乳头瘤病毒16型（HPV 16）E6变异体的致癌性增强是人群依赖性的，这意味着其他遗传辅因子的参与。本研究旨在调查日本人群中E6变异体与人类白细胞抗原（HLA）多态性之间的关联。分析了57例HPV 16阳性宫颈癌患者E6序列变异及其与HLA 11类等位基因的关系。与当地对照组（n = 138）和已发表的对照组（n = 916）相比，HPV 16 E6原型患者（n = 11）中DRB 1 *1501和DQB 1 *0602的频率显著增加。此外，DRB 1 *1502与指定为D25 E的特定E6变体正相关（n = 25），尽管我们没有发现HLA 11类等位基因与L 83 V变体之间的显著关联（n = 16）。我们的观察表明，E6变异蛋白和HLA类型之间的特定匹配可能有助于HPV 16相关的宫颈癌发生。(C)2003 Wiley-Liss，Inc.
The enhanced oncogenicity of particular human papillomavirus type 16 (HPV16) E6 variants is population-dependent, implying the involvement of additional genetic cofactors. This study was designed to investigate the association between E6 variants and human leukocyte antigen (HLA) polymorphism within a Japanese population. Fifty-seven women with HPV16-positive cervical cancer were analyzed for E6 sequence variation and its relationship to HLA class 11 alleles. Compared with local controls (n = 138) and published controls (n = 916), DRB1*1501 and DQB1*0602 frequencies were significantly increased among patients with HPV16 E6 prototype (n = 11). Additionally, DRB1*1502 was positively associated with a particular E6 variant designated D25E (n = 25), although we could not find a significant association between HLA class 11 alleles and L83V variants (n = 16). Our observations suggest that a specific match between E6 variant proteins and HLA types may contribute to HPV16-related cervical carcinogenesis. (C) 2003 Wiley-Liss, Inc.