The extracellular matrix in wound healing: a closer look at therapeutics for chronic wounds.
The extracellular matrix in wound healing: a closer look at therapeutics for chronic wounds.
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DOI：
10.1177/1534734607301394
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发表时间：
2007-06-01
期刊：
影响因子：
--
通讯作者：
Werthen, Maria
中科院分区：
文献类型：
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作者：
Agren, Magnus S;Werthen, Maria
在慢性伤口中使用外源性重组生长因子的令人失望的结果已经将焦点重新导向细胞外基质（ECM）。新的研究已经清楚地改变了我们对ECM在组织修复中的作用的看法，并驳斥了ECM的唯一功能是对细胞的被动物理支持的教条。现在清楚的是，完整的或片段化的ECM分子能够主要通过整合素相互作用与生长因子活化一起转导对于伤口愈合中的细胞过程至关重要的信号。此外，我们对具有生物活性但没有显著结构影响的微小浓度ECM分子的了解正在增加。本文综述了ECM在正常伤口愈合过程中的多方面分子作用和慢性伤口中的一些分子异常，并基于组织生物学的发展探讨了潜在的治疗方法。
Disappointing results with the use of exogenous recombinant growth factors in chronic wounds have redirected the focus to the extracellular matrix (ECM). Newer research has clearly changed our view on the role of the ECM in tissue repair and dismissed the dogma that the sole function of ECM is a passive physical support for cells. It is now clear that intact or fragmented ECM molecules are capable of transducing signals pivotal for cell processes in wound healing primarily via integrin interactions in concert with growth factor activation. In addition, our knowledge about ECM molecules in minute concentrations with biological activity, but devoid of significant structural influence, is increasing. This article reviews the multifaceted molecular roles of ECM in the normal wound-healing process and some molecular abnormalities in chronic wounds, and touches on potential therapies based on the developments of tissue biology.