Effective Iron Chelation following Oral Administration of an Isoniazid‐Pyridoxal Hydrazone
Effective Iron Chelation following Oral Administration of an Isoniazid‐Pyridoxal Hydrazone
复制标题
口服异烟肼-吡哆醛腙后有效的铁螯合
DOI：
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发表时间：
1979
影响因子：
6.5
通讯作者：
P. Ponka
中科院分区：
文献类型：
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作者：
T. Hoy;J. Humphrys;A. Jacobs;A. Williams;P. Ponka
总结。当异烟肼和吡哆醛以等摩尔量混合时，形成能与铁络合的腙。大鼠单次口服该化合物25-100 mg/kg可导致铁排泄量增加至正常水平的8倍。在组织培养中，该化合物能够从Chang细胞中去除铁。结果表明，该化合物可能具有口服治疗铁超载的潜在价值。
Summary. When isoniazid and pyridoxal are mixed in equimolar quantities a hydrazone is formed which is able to complex with iron. The oral administration of this compound to rats in single doses of 25–100 mg/kg leads to an increase in faecal iron excretion up to 8 times the normal level. In tissue culture the compound is able to remove iron from Chang cells. The results suggest that this compound may be of potential value for the oral therapy of iron overload.